Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6678914
rs6678914
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.710 GeneticVariation BEFREE Using the chi-squared (χ<sup>2</sup>) test and genetic model analysis, we found an association with BC for four SNPs (rs616488 (1p36.22/PEX14), rs6678914 (1q32.1/LGR6), rs17530068 (6q14/unknown) and rs6001930 (22q13.1/MKL1)) at a 5% level. 27604554 2016
dbSNP: rs6678914
rs6678914
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0678222
Disease:
Breast Carcinoma 		0.710 GeneticVariation BEFREE Using the chi-squared (χ<sup>2</sup>) test and genetic model analysis, we found an association with BC for four SNPs (rs616488 (1p36.22/PEX14), rs6678914 (1q32.1/LGR6), rs17530068 (6q14/unknown) and rs6001930 (22q13.1/MKL1)) at a 5% level. 27604554 2016
dbSNP: rs6678914
rs6678914
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0678222
Disease:
Breast Carcinoma 		0.710 GeneticVariation GWASCAT Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733 2013
dbSNP: rs6678914
rs6678914
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.710 GeneticVariation GWASDB Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733 2013
dbSNP: rs17489300
rs17489300
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0678222
Disease:
Breast Carcinoma 		0.700 GeneticVariation GWASCAT Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. 27117709 2016
dbSNP: rs1457668577
rs1457668577
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE GRK4 is implicated in the regulation of blood pressure, and three GRK4 polymorphisms (R65L, A142V, and A486V) are associated with hypertension. 26134571 2015
dbSNP: rs77340941
rs77340941
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4. 26134571 2015
dbSNP: rs6678914
rs6678914
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0279563
Disease:
Lobular carcinoma in situ of breast 		0.010 GeneticVariation BEFREE Two SNPs showed significantly stronger associations for ILC than LCIS (rs2981579/10q26/FGFR2, P-het = 0.04 and rs889312/5q11/MAP3K1, P-het = 0.03); and two showed stronger associations for LCIS than ILC (rs6678914/1q32/LGR6, P-het = 0.001 and rs1752911/6q14, P-het = 0.04). 24743323 2014
dbSNP: rs561224262
rs561224262
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE The 901G > A polymorphism of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China. 24073849 2013
dbSNP: rs866514672
rs866514672
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population. 22180093 2012
dbSNP: rs747112750
rs747112750
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
CUI: C0948089
Disease:
Acute Coronary Syndrome 		0.010 GeneticVariation BEFREE While the platelet glycoprotein IIb/IIIa is involved in the pathogenesis of acute coronary syndromes whereas most platelet activating stimuli act via G Protein coupled receptors we investigated whether the 825C>T polymorphism of the gene GNB3 encoding the G protein beta3 subunit together with the platelet glycoprotein (GP) IIIa Pl(A) polymorphism are predictive of platelet aggregability on stimulation with various agonists acting via GPCRs. 12818251 2003