RGS7, regulator of G protein signaling 7, 6000

N. diseases: 28; N. variants: 25
Disease: Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs755007339
rs755007339
Entrez Id: 6000
Gene Symbol: RGS7
RGS7
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE By mutating position 56 in the R44C mutant from valine to cysteine, thereby enabling the formation of a disulfide bridge between the two mutated positions, we slightly increased the catalytic activity and reinstated protein stability, leading to the rescue of RGS7's function as a tumor suppressor. 29330521 2018