RNASE3, ribonuclease A family member 3, 6037

N. diseases: 207; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2073342
rs2073342
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024534
Disease:
Malaria, Cerebral 		0.020 GeneticVariation BEFREE RNASE3 (ECP) has been identified as an inhibitor of Plasmodium parasites growth in vitro, and genetic analysis in hospitalized Ghanaian subjects has revealed the RNASE3 +371G/C (rs2073342) polymorphism as a susceptibility factor for cerebral malaria. 29402293 2018
dbSNP: rs2073342
rs2073342
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024534
Disease:
Malaria, Cerebral 		0.020 GeneticVariation BEFREE The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively. 22216286 2011
dbSNP: rs2073342
rs2073342
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024530
Disease:
Malaria 		0.010 GeneticVariation BEFREE The polymorphisms: +371G/C (rs2073342), +499G/C (rs2233860) and +577A/T (rs8019343) defined a haplotype risk (G-G-T) for malaria severity (Fisher exact test, p = 0.03) (OR 4.1, IC 95% (1.1-14.9). 29402293 2018
dbSNP: rs2233860
rs2233860
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024530
Disease:
Malaria 		0.010 GeneticVariation BEFREE Six frequent SNPs (MAF > 3%) were identified, and one SNP was associated with malaria severity by performing a logistic regression analysis SM vs.UM: RNASE3 +499G/C (rs2233860) under age, sex as covariates and HbS/HbC polymorphisms adjustment (p = 0.003, OR 0.43, CI 95% 0.20-0.92). 29402293 2018
dbSNP: rs8019343
rs8019343
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024530
Disease:
Malaria 		0.010 GeneticVariation BEFREE The polymorphisms: +371G/C (rs2073342), +499G/C (rs2233860) and +577A/T (rs8019343) defined a haplotype risk (G-G-T) for malaria severity (Fisher exact test, p = 0.03) (OR 4.1, IC 95% (1.1-14.9). 29402293 2018
dbSNP: rs2233860
rs2233860
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024534
Disease:
Malaria, Cerebral 		0.010 GeneticVariation BEFREE The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively. 22216286 2011
dbSNP: rs8019343
rs8019343
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0024534
Disease:
Malaria, Cerebral 		0.010 GeneticVariation BEFREE The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively. 22216286 2011
dbSNP: rs2073342
rs2073342
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C2607914
Disease:
Allergic rhinitis (disorder) 		0.010 GeneticVariation BEFREE The genotype frequencies of the g.-550A>G and g.371G>C SNPs were not significantly different between patients with allergic rhinitis and controls (P > 0.05). 19760211 2010
dbSNP: rs2233859
rs2233859
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0004096
Disease:
Asthma 		0.010 GeneticVariation BEFREE The prevalence of the gene polymorphisms ECP434(G>C) (rs2073342), ECP562(G>C) (rs2233860) and ECP c.-38(A>C) (rs2233859) were analysed by DNA sequencing and/or real-time PCR and related to questionnaire-based information of allergy, asthma, smoking habits and to lung functions. 20534163 2010
dbSNP: rs2233860
rs2233860
Entrez Id: 6037;100507513
Gene Symbol: RNASE3;LOC100507513
RNASE3;LOC100507513
CUI: C0004096
Disease:
Asthma 		0.010 GeneticVariation BEFREE The prevalence of the gene polymorphisms ECP434(G>C) (rs2073342), ECP562(G>C) (rs2233860) and ECP c.-38(A>C) (rs2233859) were analysed by DNA sequencing and/or real-time PCR and related to questionnaire-based information of allergy, asthma, smoking habits and to lung functions. 20534163 2010