|
rs2067079
|
SNORD81;SNORD79;SNORD80;SNORD47;SNORD44;GAS5;SNORD77;SNORD78;SNORA103
|
Red Blood Cell Count measurement
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs2208849
|
GAS5;GAS5-AS1
|
Intelligence
|
|
0.700 |
GeneticVariation |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Neoplasm Metastasis
|
|
0.030 |
GeneticVariation |
BEFREE |
The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.
|
29557411 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Neoplasm Metastasis
|
|
0.030 |
GeneticVariation |
BEFREE |
We confirmed that rs145204276 of GAS5 is a functional variant associated with the susceptibility and metastasis of GC.
|
29602737 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer.
|
30013899 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma.
|
29207621 |
2017 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility and progression of CRC.
|
27863421 |
2016 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Neoplasm Metastasis
|
|
0.030 |
GeneticVariation |
BEFREE |
In current two-stage, case-control study, we systematically evaluated the potential role of lncRNA GAS5 and its genetic variation rs145204276 in the development and metastasis process of CRC in a Chinese population.
|
27863421 |
2016 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with PC were recruited and grouped according to their specific genotypes of rs55829688 and rs145204276.
|
30317620 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics.
|
31673232 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with PC were recruited and grouped according to their specific genotypes of rs55829688 and rs145204276.
|
30317620 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation |
BEFREE |
We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics.
|
31673232 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of the allele del of rs145204276 were compared between the patients and the controls to evaluate the impact of tumor susceptibility and the correlation of clinicopathological variables.
|
31673232 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant rs145204276 of GAS5 is associated with the development and prognosis of GC.
|
29557411 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant rs145204276 of GAS5 is associated with the development and prognosis of GC.
|
29557411 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
We confirmed that rs145204276 of GAS5 is a functional variant associated with the susceptibility and metastasis of GC.
|
29602737 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
We confirmed that rs145204276 of GAS5 is a functional variant associated with the susceptibility and metastasis of GC.
|
29602737 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Liver carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer.
|
30013899 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer.
|
30013899 |
2018 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation |
BEFREE |
In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma.
|
29207621 |
2017 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility of lung cancer, and GAS5 functions as a tumor suppressor in carcinogenesis of lung cancer.
|
29207621 |
2017 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Liver carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma.
|
29207621 |
2017 |
|
rs55829688
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph </span>node metastasis.
|
31673232 |
2019 |
|
rs145204276
|
GAS5;ZBTB37;SNORD74;SNORD75;SNORD76;SNORD77;SNORA103
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation |
BEFREE |
The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins.
|
31673232 |
2019 |