Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE Here we report that DS-6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizotinib-resistant ROS1 positive cancer with secondary kinase domain mutations especially G2032R mutation which is highly resistant to crizotinib as well as lorlatinib and entrectinib, next generation ROS1 inhibitors. 31399568 2019
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE The effect of the identified drug was assessed in the CD74-ROS1-mutant Ba/F3 cells and crizotinib-resistant patient-derived cancer cells (MGH047) harboring G2032R-mutated CD74-ROS1. 25351743 2015
dbSNP: rs1213277193
rs1213277193
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE Together, F-1 is validated as a promising ALK/ROS1 dual inhibitor great potential for G1202R ALK mutation cancers. 30223120 2018