CXCL12, C-X-C motif chemokine ligand 12, 6387

N. diseases: 626; N. variants: 21
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE <i>SDF-1</i> rs1801157 polymorphism may not influence the risk of SLE. 29088886 2017
dbSNP: rs17885289
rs17885289
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0302592
Disease:
Cervix carcinoma
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs17885289
rs17885289
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0007847
Disease:
Malignant tumor of cervix
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs17885289
rs17885289
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C4048328
Disease:
cervical cancer
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0302592
Disease:
Cervix carcinoma
0.020 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C4048328
Disease:
cervical cancer
0.020 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0007847
Disease:
Malignant tumor of cervix
0.020 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266093
rs266093
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0302592
Disease:
Cervix carcinoma
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266093
rs266093
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C4048328
Disease:
cervical cancer
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs266093
rs266093
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0007847
Disease:
Malignant tumor of cervix
0.010 GeneticVariation BEFREE A stepwise procedure identified rs17885289, rs266085 and 3'-untranslated region (UTR) SNP rs266093 as the most parsimonious subset of SNPs necessary to define the haplotype inversely associated with cervical cancer risk in our study. 19788587 2009
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0019693
Disease:
HIV Infections
0.010 GeneticVariation BEFREE After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06). 30921390 2019
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0275524
Disease:
Coinfection
0.010 GeneticVariation BEFREE After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06). 30921390 2019
dbSNP: rs2839693
rs2839693
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0036690
Disease:
Septicemia
0.010 GeneticVariation BEFREE Among the 13 tag single nucleotide polymorphisms, four single nucleotide polymorphisms (rs1429638, rs266087, rs2297630, and rs2839693) were significantly associated with the susceptibility to sepsis, and three (rs3117604, rs1429638, and rs4074) were significantly associated with an increased multiple organ dysfunction score in the derivation cohort. 30489503 2019
dbSNP: rs2839693
rs2839693
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0243026
Disease:
Sepsis
0.010 GeneticVariation BEFREE Among the 13 tag single nucleotide polymorphisms, four single nucleotide polymorphisms (rs1429638, rs266087, rs2297630, and rs2839693) were significantly associated with the susceptibility to sepsis, and three (rs3117604, rs1429638, and rs4074) were significantly associated with an increased multiple organ dysfunction score in the derivation cohort. 30489503 2019
dbSNP: rs266089
rs266089
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027051
Disease:
Myocardial Infarction
0.700 GeneticVariation GWASDB Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. 21211798 2011
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0398650
Disease:
Immune thrombocytopenic purpura
0.010 GeneticVariation BEFREE Compared with controls, the rs2839693 A/A and rs266085 C/T genotypes were decreased in ITP patients (P = 0.004 and 0.007, respectively). 23078136 2013
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes. 29893194 2018
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. 19927352 2009
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0678222
Disease:
Breast Carcinoma
0.060 GeneticVariation BEFREE CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. 19927352 2009
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C4721532
Disease:
Lymphoma, Non-Hodgkin, Familial
0.010 GeneticVariation BEFREE CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. 19927352 2009
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0220605
Disease:
Adult Non-Hodgkin Lymphoma
0.010 GeneticVariation BEFREE CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. 19927352 2009
dbSNP: rs1801157
rs1801157
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0220612
Disease:
Childhood Non-Hodgkin Lymphoma
0.010 GeneticVariation BEFREE CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. 19927352 2009
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0302592
Disease:
Cervix carcinoma
0.020 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C4048328
Disease:
cervical cancer
0.020 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015
dbSNP: rs266085
rs266085
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0007847
Disease:
Malignant tumor of cervix
0.020 GeneticVariation BEFREE CXCL12 rs266085 and TNF-α rs1799724 polymorphisms and susceptibility to cervical cancer in a Chinese population. 26191295 2015