SLC22A4, solute carrier family 22 member 4, 6583

N. diseases: 90; N. variants: 21
Disease: pathologic fistula ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0016169
Disease:
pathologic fistula 		0.010 GeneticVariation BEFREE We found statistically significant association of polymorphisms rs1050152 in gene SLC22A4 (p = 0.005, OR = 2.177, 95% CI = 1.270-3.526) and rs2631372 in gene SLC22A5 (p = 0.001, OR = 0.473, 95% CI = 0.307-0.731) and TC haplotype of both polymorphisms (p = 0.006, OR = 1,541, 95% CI = 1.130-2.100) with refractory Crohn's disease (CD) in Slovenian patients who do not respond to standard therapy, including patients who develop fistulas. 21695374 2011