Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1517352
rs1517352
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
C 0.700 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.040 GeneticVariation BEFREE STAT4 rs7574865 gene is IBD risk factor, and this gene polymorphism is associated with UC susceptibility, especially in Caucasians. 26066297 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.040 GeneticVariation BEFREE Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease. 23628400 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.040 GeneticVariation BEFREE However, the meta-analysis showed that the STAT4 rs7574865 T allele was significantly associated with susceptibility to UC (p = 0.012 pooled; OR = 1.20, 95% CI = 1.04-1.39) but not CD (p = 0.71 pooled; OR = 0.93, 95% CI = 0.65-1.34). 20153791 2010
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.040 GeneticVariation BEFREE The association of STAT4 polymorphism rs7574865 with RA was validated in patients of Spanish origin (for T versus G, P = 1.2 x 10(-6), odds ratio [OR] 1.59, 95% confidence interval [95% CI] 1.31-1.92), and the association was described for the first time in both clinical forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis (for T versus G, P = 0.006, OR 1.29, 95% CI 1.07-1.55), and in type 1 diabetes mellitus (for T versus G, P = 0.008, OR 1.36, 95% CI 1.07-1.71). 18759272 2008
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.010 GeneticVariation BEFREE Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238). 20454450 2010
dbSNP: rs11889341
rs11889341
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0009324
Disease:
Ulcerative Colitis
0.010 GeneticVariation BEFREE Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR=3.79), and between SNP rs925847 and eye involvement (P=0.030; OR=2.42) in UC patients. 20176035 2010
dbSNP: rs925847
rs925847
Entrez Id: 6775;105373805
Gene Symbol: STAT4;LOC105373805
STAT4;LOC105373805
CUI: C0009324
Disease:
Ulcerative Colitis
0.010 GeneticVariation BEFREE SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR=0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. 20176035 2010