TACR1, tachykinin receptor 1, 6869

N. diseases: 217; N. variants: 10
Disease: Bipolar Disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1106854
rs1106854
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE A mutation in intron four, rs1106854, was associated with BPAD, although a regulatory role for rs1106854 is unclear. 24817687 2014
dbSNP: rs3771829
rs3771829
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence. 24817687 2014
dbSNP: rs3771856
rs3771856
Entrez Id: 6869;105374811;105374812
Gene Symbol: TACR1;LOC105374811;LOC105374812
TACR1;LOC105374811;LOC105374812
CUI: C0005586
Disease:
Bipolar Disorder 		0.010 GeneticVariation BEFREE Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010