HNF1A, HNF1 homeobox A, 6927

N. diseases: 292; N. variants: 105
Disease: Coronary heart disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2259816
rs2259816
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		0.820 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
dbSNP: rs2259816
rs2259816
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		0.820 GeneticVariation BEFREE Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002). 22152955 2011
dbSNP: rs2259816
rs2259816
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		0.820 GeneticVariation BEFREE In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease. 21062467 2010
dbSNP: rs2259816
rs2259816
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		T 0.820 GeneticVariation GWASCAT New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
dbSNP: rs2259816
rs2259816
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		T 0.820 GeneticVariation GWASDB New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0010068
Disease:
Coronary heart disease 		0.010 GeneticVariation BEFREE The HNF1A Ser486Asn and/or Ile27Leu variants were also associated with increased risk of subclinical coronary atherosclerosis in Coronary Artery Risk Development in Young Adults and with incident coronary heart disease in Cardiovascular Health Study. 20031592 2009
dbSNP: rs2464196
rs2464196
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0010068
Disease:
Coronary heart disease 		0.010 GeneticVariation BEFREE The HNF1A Ser486Asn and/or Ile27Leu variants were also associated with increased risk of subclinical coronary atherosclerosis in Coronary Artery Risk Development in Young Adults and with incident coronary heart disease in Cardiovascular Health Study. 20031592 2009