HNF1B, HNF1 homeobox B, 6928

N. diseases: 279; N. variants: 72
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4430796
rs4430796
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa. 24627192 2014
dbSNP: rs4430796
rs4430796
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE The per-T2D-risk-allele odds ratios (95% confidence intervals) for rs4430796 were 0.79 (0.76, 0.83)] per G allele for prostate cancer (p<10(-15) for both); and 1.03 (0.99, 1.07) for all other cancers. 20526366 2010
dbSNP: rs11263763
rs11263763
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. 25378557 2015
dbSNP: rs7501939
rs7501939
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE In a collaborative analysis, we collected data from GWAS of cancer phenotypes for the frequently reported variants of HNF1B, rs4430796 and rs7501939, which are in linkage disequilibrium (r(2) = 0.76, HapMap CEU). 20526366 2010