|
rs2043556
|
PRKG1;MIR605
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings did not support an association between miR-100 rs1834306, miR-124-1 rs531564, miR-605 rs2043556 and miR-4293 rs12220909 polymorphism and the risk of BC.
|
29317318 |
2018 |
|
rs2043556
|
PRKG1;MIR605
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings did not support an association between miR-100 rs1834306, miR-124-1 rs531564, miR-605 rs2043556 and miR-4293 rs12220909 polymorphism and the risk of BC.
|
29317318 |
2018 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4⁻0.9] <i>p</i> = 0.006 and OR = 0.6 [95% CI 0.5⁻0.9] <i>p</i> = 0.02, respectively).
|
30135399 |
2018 |
|
rs2043556
|
PRKG1;MIR605
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4⁻0.9] <i>p</i> = 0.006 and OR = 0.6 [95% CI 0.5⁻0.9] <i>p</i> = 0.02, respectively).
|
30135399 |
2018 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation |
BEFREE |
To explore the relevance of miRNA polymorphisms and female physiological characteristics to breast cancer risk, SNPs located within hsa-miR-605 (rs2043556), hsa-miR-149 (rs2292832), hsa-miR-27a (rs895819), hsa-miR-196a-2 (rs11614913) and hsa-miR-618 (rs2682818) were selected, and their associations with breast cancer risk were analysed.
|
22074121 |
2012 |
|
rs2043556
|
PRKG1;MIR605
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
To explore the relevance of miRNA polymorphisms and female physiological characteristics to breast cancer risk, SNPs located within hsa-miR-605 (rs2043556), hsa-miR-149 (rs2292832), hsa-miR-27a (rs895819), hsa-miR-196a-2 (rs11614913) and hsa-miR-618 (rs2682818) were selected, and their associations with breast cancer risk were analysed.
|
22074121 |
2012 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
We hypothesized that, if functional, the miR-605 gene and its variant (rs2043556) could impact the cancer risk profile of TP53 mutation carriers.
|
25683625 |
2015 |
|
rs2043556
|
PRKG1;MIR605
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
We hypothesized that, if functional, the miR-605 gene and its variant (rs2043556) could impact the cancer risk profile of TP53 mutation carriers.
|
25683625 |
2015 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation |
BEFREE |
With a novel statistic, Cross phenotype meta-analysis (CPMA) of the association of MirSNPs with multiple phenotypes indicated rs2910164 C (P = 1.11E-03), rs2043556 C (P = 0.0165), rs6505162 C (P = 2.05E-03) and rs895819 (P = 0.0284) were associated with a significant overall risk of cancer.
|
24413317 |
2014 |
|
rs2043556
|
PRKG1;MIR605
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation |
BEFREE |
With a novel statistic, Cross phenotype meta-analysis (CPMA) of the association of MirSNPs with multiple phenotypes indicated rs2910164 C (P = 1.11E-03), rs2043556 C (P = 0.0165), rs6505162 C (P = 2.05E-03) and rs895819 (P = 0.0284) were associated with a significant overall risk of cancer.
|
24413317 |
2014 |
|
rs2043556
|
PRKG1;MIR605
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The MIR605 rs2043556 G allele was detected in 136 (57.1%) individuals, including 25 homozygotes (10.5%), and although it had been previously associated with an earlier mean age of tumor onset, this effect was not observed in this study (p = 0.8).
|
31778928 |
2020 |
|
rs2043556
|
PRKG1;MIR605
|
Li-Fraumeni Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, the functional MIR605 variant rs2043556 (A>G) has been identified as a novel LFS phenotype modifier in families with germline TP53 DNA binding variants.
|
31778928 |
2020 |
|
rs2043556
|
PRKG1;MIR605
|
Angina, Unstable
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the <i>miR-605</i> rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, <i>P</i> = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, <i>P</i> = .008) in ACS patients receiving clopidogrel therapy for more than one year.
|
31766967 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the <i>miR-605</i> rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, <i>P</i> = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, <i>P</i> = .008) in ACS patients receiving clopidogrel therapy for more than one year.
|
31766967 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
cervical cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
|
30852614 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the <i>miR-605</i> rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, <i>P</i> = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, <i>P</i> = .008) in ACS patients receiving clopidogrel therapy for more than one year.
|
31766967 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation |
BEFREE |
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
|
30852614 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
|
30852614 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients.
|
31766967 |
2019 |
|
rs2043556
|
PRKG1;MIR605
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether three common microRNA polymorphisms (miR-21T>C [rs1292037], miR-126G>A [rs4636297] and miR-605T>C [rs2043556]) were associated with ischemic stroke (IS) risk in a Chinese population.
|
29221163 |
2017 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the associations of SNPs within hsa-miR-605 (rs2043556) and hsa-miR-149 (rs2292832) and lifestyle-related factors with gastrointestinal cancer, a case-control study including 762 cases and 757 controls was conducted.
|
21976437 |
2012 |
|
rs2043556
|
PRKG1;MIR605
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of rs2292832 and rs2043556 might be able to modify the susceptibility to male gastric and colorectal cancers, respectively.
|
21976437 |
2012 |
|
rs2043556
|
PRKG1;MIR605
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation |
BEFREE |
Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48-1.02) in males.
|
21976437 |
2012 |