TCN2, transcobalamin 2, 6948

N. diseases: 104; N. variants: 30
Disease: Down Syndrome ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801198
rs1801198
Entrez Id: 6948
Gene Symbol: TCN2
TCN2
CUI: C0013080
Disease:
Down Syndrome 		0.020 GeneticVariation BEFREE The polymorphisms transcobalamin II (TCN2) c.776C>G, betaine-homocysteine S-methyltransferase (BHMT) c.742A>G, methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) c.677 C>T and the MTHFR 677C-1298A-1317T haplotype modulate DS risk. 22377700 2012
dbSNP: rs1801198
rs1801198
Entrez Id: 6948
Gene Symbol: TCN2
TCN2
CUI: C0013080
Disease:
Down Syndrome 		0.020 GeneticVariation BEFREE There was no evidence of any association between the RFC1 A80G and TC2 C776G polymorphisms and the maternal risk of DS in the sample evaluated. 19274320 2008
dbSNP: rs1465444723
rs1465444723
Entrez Id: 6948
Gene Symbol: TCN2
TCN2
CUI: C0013080
Disease:
Down Syndrome 		0.010 GeneticVariation BEFREE There was no evidence of any association between the RFC1 A80G and TC2 C776G polymorphisms and the maternal risk of DS in the sample evaluated. 19274320 2008