TLR2, toll like receptor 2, 7097

N. diseases: 749; N. variants: 15
Disease: Acute focal bacterial nephritis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3804099
rs3804099
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C3266959
Disease:
Acute focal bacterial nephritis 		0.010 GeneticVariation BEFREE Further genotype pattern frequency analysis in TLR-2 SNPs (rs3804099 and rs3804100) showed significantly reduced occurrence of the rare allele homozygote (CC+CC) in the no-VUR subgroup of APN and ALN cases. 23484049 2013
dbSNP: rs3804100
rs3804100
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C3266959
Disease:
Acute focal bacterial nephritis 		0.010 GeneticVariation BEFREE As the inflammatory responses in ALN patients are more severe than those in APN patients (higher CRP levels, longer duration of fever after antibiotic treatment), these findings suggest that the genetic variant in TLR-2 (rs3804100, T1350C) may protect the host from severe urinary tract infections as ALN. 23484049 2013