TLR5, toll like receptor 5, 7100

N. diseases: 163; N. variants: 6
Disease: Bacteremia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5744168
rs5744168
Entrez Id: 7100
Gene Symbol: TLR5
TLR5
CUI: C0004610
Disease:
Bacteremia 		0.020 GeneticVariation BEFREE In multivariable analysis adjusting for age, sex, diabetes and renal disease, the adjusted OR for 28-day mortality in carriers of the variant was 0.24 (95% CI 0.05-1.08, P = 0.06); and the adjusted OR for 90-day mortality was 0.27 (95% CI 0.08-0.97, P = 0.04). c.1174C>T was associated with a lower rate of bacteremia (P = 0.04) and reduced plasma levels of IL-10 (P = 0.049) and TNF-α (P < 0.0001). 28475641 2017
dbSNP: rs5744168
rs5744168
Entrez Id: 7100
Gene Symbol: TLR5
TLR5
CUI: C0004610
Disease:
Bacteremia 		0.020 GeneticVariation BEFREE Associations were found between the CC genotype of IL6 SNP rs1800795 and occurrence of bacteremia and between TLR5 SNP rs5744168 and protection from UTI. 25807366 2015