TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Leukemia, Myelocytic, Acute ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.710 GeneticVariation BEFREE Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells. 30948782 2019
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs886039484
rs886039484
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.710 GeneticVariation CLINVAR Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review. 24641375 2014
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.710 GeneticVariation CLINVAR Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. 24487413 2014
dbSNP: rs11540652
rs11540652
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.710 GeneticVariation CLINVAR Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. 24381225 2014
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs886039484
rs886039484
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.710 GeneticVariation BEFREE We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML. 23167335 2012
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.710 GeneticVariation BEFREE We have recently established the MV4-11 acute myelogenous leukemia (AML) subline, designated as MV4-11 TP53 R248W, which possesses a missense mutation (CGG→TGG; R248W) in the TP53 gene, leading to inactivation of this transcription factor. 21550660 2011
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.710 GeneticVariation CLINVAR p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells. 20013323 2010
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.710 CausalMutation CLINVAR
dbSNP: rs1057519977
rs1057519977
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519978
rs1057519978
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519978
rs1057519978
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519978
rs1057519978
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519985
rs1057519985
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519985
rs1057519985
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057519991
rs1057519991
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs1057520003
rs1057520003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121912660
rs121912660
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121913343
rs121913343
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016