TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Retinoblastoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0035335
Disease:
Retinoblastoma 		0.020 GeneticVariation BEFREE The rs9568036 polymorphism in the <i>RB1</i> gene and the allelic variants can be associated with type of response to medical therapy and associated with male sex, while the allelic variant rs1042522 polymorphism in the <i>TP53</i> gene is associated with the unilateral presentation of the disease in a group of Mexican children with RB. 28210099 2017
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0035335
Disease:
Retinoblastoma 		0.020 GeneticVariation BEFREE However, the rs1042</span>522 GC genotype showed a protective effect against RB invasion, as demonstrated by event-free survival (HR = 0.53, P = 0.007 for GC versus GG/CC). 26289323 2015
dbSNP: rs55819519
rs55819519
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0035335
Disease:
Retinoblastoma 		0.010 GeneticVariation BEFREE Using immunohistochemistry, we investigated expression of R132H IDH1, and p53 and retinoblastoma pathways. 22674453 2012