DIRC3, disrupted in renal carcinoma 3, 729582

N. diseases: 16; N. variants: 19
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs966423
rs966423
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		0.820 GeneticVariation BEFREE Five single nucleotide polymorphisms (SNPs) were previously reported to be associated with thyroid cancer in European populations in two genome-wide association studies (GWAS): rs965513 (9q22.33), rs944289 (14q13.3), rs116909374 (14q13.3), rs966423 (2q35) and rs2439302 (8p12). 23847140 2013
dbSNP: rs966423
rs966423
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		0.820 GeneticVariation BEFREE After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. 22267200 2012
dbSNP: rs966423
rs966423
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		C 0.820 GeneticVariation GWASDB After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. 22267200 2012
dbSNP: rs966423
rs966423
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		C 0.820 GeneticVariation GWASCAT After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. 22267200 2012
dbSNP: rs6759952
rs6759952
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		T 0.800 GeneticVariation GWASDB Genome-wide association study on differentiated thyroid cancer. 23894154 2013
dbSNP: rs6759952
rs6759952
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		T 0.800 GeneticVariation GWASCAT Genome-wide association study on differentiated thyroid cancer. 23894154 2013
dbSNP: rs10168801
rs10168801
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0042834
Disease:
Vital capacity 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1864439
rs1864439
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs2373078
rs2373078
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0205682
Disease:
Waist-Hip Ratio 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs2618152
rs2618152
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0424678
Disease:
Lean body mass 		0.700 GeneticVariation GWASCAT Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. 30593698 2019
dbSNP: rs4294980
rs4294980
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0042834
Disease:
Vital capacity 		A 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs4294980
rs4294980
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0016529
Disease:
Forced expiratory volume function 		A 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs6759952
rs6759952
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs727511
rs727511
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7579468
rs7579468
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0205682
Disease:
Waist-Hip Ratio 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs994532
rs994532
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
dbSNP: rs6724073
rs6724073
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
dbSNP: rs11693806
rs11693806
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0678222
Disease:
Breast Carcinoma 		G 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs11693806
rs11693806
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0549473
Disease:
Thyroid carcinoma 		C 0.700 GeneticVariation GWASCAT A genome-wide association study yields five novel thyroid cancer risk loci. 28195142 2017
dbSNP: rs12990503
rs12990503
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0238463
Disease:
Papillary thyroid carcinoma 		G 0.700 GeneticVariation GWASCAT Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. 28703219 2017
dbSNP: rs12990503
rs12990503
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C1337013
Disease:
Differentiated Thyroid Gland Carcinoma 		G 0.700 GeneticVariation GWASCAT Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. 28703219 2017
dbSNP: rs16857609
rs16857609
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs77119843
rs77119843
Entrez Id: 729582;105373877
Gene Symbol: DIRC3;DIRC3-AS1
DIRC3;DIRC3-AS1
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		C 0.700 GeneticVariation GWASCAT A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease. 26503814 2016
dbSNP: rs16857609
rs16857609
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.700 GeneticVariation GWASCAT Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 25751625 2015
dbSNP: rs200179115
rs200179115
Entrez Id: 729582;105373877
Gene Symbol: DIRC3;DIRC3-AS1
DIRC3;DIRC3-AS1
CUI: C0016529
Disease:
Forced expiratory volume function 		AG 0.700 GeneticVariation GWASCAT Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. 26423011 2015