TFPI2, tissue factor pathway inhibitor 2, 7980

N. diseases: 161; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34489123
rs34489123
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.020 GeneticVariation BEFREE We found that the A allele of rs34489123 and the G allele of rs4264 within TFPI-2 gene, interaction between rs34489123 and smoking and AG haplotypes were all associated with increased coronary atherosclerosis risk. 30343349 2019
dbSNP: rs34489123
rs34489123
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.020 GeneticVariation BEFREE After the baseline investigation, patients with coronary atherosclerosis</span> were followed up for incidence of cardiovascular events (CVEs).Eight SNPs were in accordance with the Hardy-Weinberg equilibrium, and 8 haplotypes were constructed based on rs59999573, rs59740167, and rs34489123 after linkage disequilibrium and haplotype analysis. 26496276 2015
dbSNP: rs4264
rs4264
Entrez Id: 2792;7980
Gene Symbol: GNGT1;TFPI2
GNGT1;TFPI2
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.010 GeneticVariation BEFREE We found that the A allele of rs34489123 and the G allele of rs4264 within TFPI-2 gene, interaction between rs34489123 and smoking and AG haplotypes were all associated with increased coronary atherosclerosis risk. 30343349 2019
dbSNP: rs59805398
rs59805398
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.010 GeneticVariation BEFREE Two SNPs (rs59805398 and rs34489123) and 5 haplotypes correlated with coronary atherosclerosis even after adjustment by Gensini score. 26496276 2015
dbSNP: rs4517
rs4517
Entrez Id: 2792;7980
Gene Symbol: GNGT1;TFPI2
GNGT1;TFPI2
CUI: C0520679
Disease:
Sleep Apnea, Obstructive 		0.010 GeneticVariation BEFREE Haplotype H1 (TCC) and H3 (CCC) defined as SNPrs5415, rs4517 and rs5435 are marginally associated with OSAS (P < 0.05). 24410986 2014
dbSNP: rs765431049
rs765431049
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT). 14525759 2004
dbSNP: rs765431049
rs765431049
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0016057
Disease:
Fibrosarcoma 		0.010 GeneticVariation BEFREE To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT). 14525759 2004
dbSNP: rs765431049
rs765431049
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0278595
Disease:
Adult Fibrosarcoma 		0.010 GeneticVariation BEFREE To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT). 14525759 2004
dbSNP: rs765431049
rs765431049
Entrez Id: 2792;7980;105375401
Gene Symbol: GNGT1;TFPI2;LOC105375401
GNGT1;TFPI2;LOC105375401
CUI: C0027627
Disease:
Neoplasm Metastasis 		0.010 GeneticVariation BEFREE To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT). 14525759 2004