DisGeNET - a database of gene-disease associations

THSD4, thrombospondin type 1 domain containing 4, 79875

N. diseases: 22; N. variants: 20

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2044029

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0035227
Disease:

Respiratory Function Tests

0.800

GeneticVariation

GWASDB

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

22837378

2012

dbSNP:

rs2044029

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0035227
Disease:

Respiratory Function Tests

0.800

GeneticVariation

GWASCAT

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

22837378

2012

dbSNP:

rs12102112

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C1518922
Disease:

peak expiratory flow (procedure)

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0016529
Disease:

Forced expiratory volume function

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs2119568

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

30804561

2019

dbSNP:

rs28529655

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

30578418

2019

dbSNP:

rs62015883

Entrez Id:	79875;107984716
Gene Symbol:	THSD4;LOC107984716

THSD4;LOC107984716

CUI:	C0016529
Disease:

Forced expiratory volume function

0.700

GeneticVariation

GWASCAT

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

30804560

2019

dbSNP:

rs1441357

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0410702
Disease:

Adolescent idiopathic scoliosis

0.700

GeneticVariation

GWASCAT

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

30019117

2018

dbSNP:

rs1441357

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C1837461
Disease:

SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3

0.700

GeneticVariation

GWASCAT

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

30019117

2018

dbSNP:

rs11631778

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

27841878

2017

dbSNP:

rs1441358

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0024117
Disease:

Chronic Obstructive Airway Disease

0.700

GeneticVariation

GWASCAT

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

28166215

2017

dbSNP:

rs142200609

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

26830138

2016

dbSNP:

rs11855326

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11855326

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11858540

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs11858540

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs12441227

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs12441227

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs12441227

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0035227
Disease:

Respiratory Function Tests

0.700

GeneticVariation

GWASCAT

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs1441361

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs1441361

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs17786786

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014

dbSNP:

rs17786786

Entrez Id:	79875
Gene Symbol:	THSD4

THSD4

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association study of lung function phenotypes in a founder population.

23932459

2014