TNKS2, tankyrase 2, 80351

N. diseases: 25; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs147689733
rs147689733
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.700 GeneticVariation GWASDB Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395 2014
dbSNP: rs1340420
rs1340420
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0007137
Disease:
Squamous cell carcinoma 		0.010 GeneticVariation BEFREE TNKS2 rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher SCC risk, suggesting that these two SNPs may be useful predictors of risk of developing NSCLC and SCC in this Chinese population. 26293798 2015
dbSNP: rs1340420
rs1340420
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0001418
Disease:
Adenocarcinoma 		0.010 GeneticVariation BEFREE However, patients carrying TNKS2 rs1340420 G/G and A/G genotypes were associated with a lower risk of developing NSCLC and adenocarcinoma (OR=0.14; 95% CI=0.02-1.15 and OR=0.11; 95% CI=0.03-0.91, respectively), whereas females patients homozygous for the TNKS2 rs1770474 T allele, a rare type, were associated with a higher risk of developing squamous-cell carcinoma (SCC) (OR=4.67; 95% CI=0.87-25.01). 26293798 2015
dbSNP: rs1340420
rs1340420
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.010 GeneticVariation BEFREE TNKS2 rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher SCC risk, suggesting that these two SNPs may be useful predictors of risk of developing NSCLC and SCC in this Chinese population. 26293798 2015
dbSNP: rs1770474
rs1770474
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0001418
Disease:
Adenocarcinoma 		0.010 GeneticVariation BEFREE However, patients carrying TNKS2 rs1340420 G/G and A/G genotypes were associated with a lower risk of developing NSCLC and adenocarcinoma (OR=0.14; 95% CI=0.02-1.15 and OR=0.11; 95% CI=0.03-0.91, respectively), whereas females patients homozygous for the TNKS2 rs1770474 T allele, a rare type, were associated with a higher risk of developing squamous-cell carcinoma (SCC) (OR=4.67; 95% CI=0.87-25.01). 26293798 2015
dbSNP: rs1770474
rs1770474
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0007137
Disease:
Squamous cell carcinoma 		0.010 GeneticVariation BEFREE TNKS2 rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher SCC risk, suggesting that these two SNPs may be useful predictors of risk of developing NSCLC and SCC in this Chinese population. 26293798 2015
dbSNP: rs1770474
rs1770474
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.010 GeneticVariation BEFREE TNKS2 rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher SCC risk, suggesting that these two SNPs may be useful predictors of risk of developing NSCLC and SCC in this Chinese population. 26293798 2015
dbSNP: rs10509637
rs10509637
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE The strongest association with BC susceptibility was observed for rs3785074 (TERF2, OR 0.51, 95% CI 0.31-0.83) and rs10509637 (TNKS2, OR 1.33, 95% CI 1.08-1.62). 19766477 2009
dbSNP: rs10509637
rs10509637
Entrez Id: 80351
Gene Symbol: TNKS2
TNKS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE The strongest association with BC susceptibility was observed for rs3785074 (TERF2, OR 0.51, 95% CI 0.31-0.83) and rs10509637 (TNKS2, OR 1.33, 95% CI 1.08-1.62). 19766477 2009