DisGeNET - a database of gene-disease associations

PICALM, phosphatidylinositol binding clathrin assembly protein, 8301

N. diseases: 79; N. variants: 22

Disease: Alzheimer's Disease ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs17817600

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.800

GeneticVariation

GWASCAT

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs17817600

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.800

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs867611

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

30617256

2019

dbSNP:

rs527162

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

GWAS on family history of Alzheimer's disease.

29777097

2018

dbSNP:

rs639012

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

A novel Alzheimer disease locus located near the gene encoding tau protein.

25778476

2016

dbSNP:

rs10501602

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12787412

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12790526

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12794211

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12795381

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12795833

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs12802399

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs17817648

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs17817931

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs17817992

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study of Alzheimer's disease.

22832961

2012

dbSNP:

rs592297

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.010

GeneticVariation

BEFREE

The null associations for rs592297 with AD risk need further confirmation with a larger number of participants.

31385771

2019

dbSNP:

rs11234495

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.010

GeneticVariation

BEFREE

Four SNPs (rs11234495, rs592297, rs676733, and rs3851179) in the PICALM gene were significantly associated with late-onset (LO)-AD in populations from Southwest China, whereas SNPs rs744373 (BIN1), rs9331942 (CLU), and rs670139 (MS4A4E) were linked to LO-AD in populations from East China.

25452228

2016

dbSNP:

rs676733

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.010

GeneticVariation

BEFREE

25452228

2016

dbSNP:

rs588076

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.010

GeneticVariation

BEFREE

Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD.

25169757

2014

dbSNP:

rs677909

Entrez Id:	8301
Gene Symbol:	PICALM

PICALM

CUI:	C0002395
Disease:

Alzheimer's Disease

0.010

GeneticVariation

BEFREE

Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing.

22975751

2014