CASP3, caspase 3, 836

N. diseases: 819; N. variants: 26
Disease: Alzheimer's Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1424266770
rs1424266770
Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease:
Alzheimer's Disease 		0.030 GeneticVariation BEFREE These results indicate that the alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD. 24439478 2014
dbSNP: rs1424266770
rs1424266770
Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease:
Alzheimer's Disease 		0.030 GeneticVariation BEFREE A specific polymorphism in the hemochromatosis (HFE) gene, H63D, is over-represented in neurodegenerative disorders such as amyotrophic lateral sclerosis and Alzheimer disease. 21349849 2011
dbSNP: rs1424266770
rs1424266770
Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease:
Alzheimer's Disease 		0.030 GeneticVariation BEFREE These findings support our hypothesis that the presence of the HFE H63D allele enables factors that trigger neurodegenerative processes associated with AD and predisposes cells to cytotoxcity. 20734416 2010
dbSNP: rs964793521
rs964793521
Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease:
Alzheimer's Disease 		0.010 GeneticVariation BEFREE The Dutch (E22Q) and Flemish (A21G) mutations in the betaAPP region of the amyloid precursor protein (APP) are associated with familial forms of Alzheimer dementia. 11422442 2001