Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs606231343
rs606231343
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C4225402
Disease:
PREMATURE OVARIAN FAILURE 10 		G 0.800 CausalMutation CLINVAR
dbSNP: rs138761187
rs138761187
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C4225402
Disease:
PREMATURE OVARIAN FAILURE 10 		A 0.700 CausalMutation CLINVAR
dbSNP: rs869320753
rs869320753
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C4225402
Disease:
PREMATURE OVARIAN FAILURE 10 		TTA 0.700 CausalMutation CLINVAR
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASCAT Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASDB Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009
dbSNP: rs236114
rs236114
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASCAT Loci at chromosomes 13, 19 and 20 influence age at natural menopause. 19448619 2009
dbSNP: rs236114
rs236114
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASDB Loci at chromosomes 13, 19 and 20 influence age at natural menopause. 19448619 2009
dbSNP: rs454422
rs454422
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1836231
Disease:
HIV-1, RESISTANCE TO 		0.700 GeneticVariation GWASCAT Host determinants of HIV-1 control in African Americans. 20205591 2010
dbSNP: rs454422
rs454422
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1836230
Disease:
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO 		0.700 GeneticVariation GWASCAT Host determinants of HIV-1 control in African Americans. 20205591 2010
dbSNP: rs454422
rs454422
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1836233
Disease:
AIDS, PROGRESSION TO 		0.700 GeneticVariation GWASCAT Host determinants of HIV-1 control in African Americans. 20205591 2010
dbSNP: rs454422
rs454422
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1836232
Disease:
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO 		0.700 GeneticVariation GWASCAT Host determinants of HIV-1 control in African Americans. 20205591 2010
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASCAT Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASDB Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASCAT A genome-wide association study of early menopause and the combined impact of identified variants. 23307926 2013
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.800 GeneticVariation GWASDB A genome-wide association study of early menopause and the combined impact of identified variants. 23307926 2013
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		0.800 GeneticVariation GWASDB Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. 23424626 2013
dbSNP: rs236114
rs236114
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		0.800 GeneticVariation GWASDB Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. 23424626 2013
dbSNP: rs236114
rs236114
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C0278704
Disease:
Malignant Childhood Neoplasm 		0.010 GeneticVariation BEFREE We determined serum AMH levels (a marker of ovarian reserve) in adult survivors of childhood cancer (n = 176) and studied single nucleotide polymorphisms (SNPs) previously reported to be associated with age at natural menopause: BRSK1 (rs1172822), ARHGEF7 (rs7333181), MCM8 (rs236114), PCSK1 (rs271924), IGF2R (rs9457827) and TNF (rs909253). 23360674 2013
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		G 0.800 GeneticVariation GWASCAT Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. 26414677 2015
dbSNP: rs606231343
rs606231343
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C4225402
Disease:
PREMATURE OVARIAN FAILURE 10 		0.800 GeneticVariation UNIPROT Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability. 25437880 2015
dbSNP: rs451417
rs451417
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C1629609
Disease:
Age at menopause 		A 0.700 GeneticVariation GWASCAT Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. 26414677 2015
dbSNP: rs768687295
rs768687295
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C0085215
Disease:
Ovarian Failure, Premature 		0.010 GeneticVariation BEFREE Our result suggests novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for POI by dysfunctional DNA repair. 27573988 2016
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C2242776
Disease:
Plexiform leiomyoma 		A 0.700 GeneticVariation GWASCAT Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits. 30194396 2018
dbSNP: rs16991615
rs16991615
Entrez Id: 84515
Gene Symbol: MCM8
MCM8
CUI: C0042133
Disease:
Uterine Fibroids 		A 0.700 GeneticVariation GWASCAT Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits. 30194396 2018