SPPL2A, signal peptide peptidase like 2A, 84888

N. diseases: 22; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12915708
rs12915708
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337428
Disease:
Fibrinogen assay 		C 0.800 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs12915708
rs12915708
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337428
Disease:
Fibrinogen assay 		C 0.800 GeneticVariation GWASCAT Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs8035452
rs8035452
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0002395
Disease:
Alzheimer's Disease 		T 0.800 GeneticVariation GWASCAT Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
dbSNP: rs8035452
rs8035452
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0002395
Disease:
Alzheimer's Disease 		T 0.800 GeneticVariation GWASDB Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
dbSNP: rs12912192
rs12912192
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12913657
rs12913657
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337434
Disease:
Estradiol measurement 		C 0.700 GeneticVariation GWASCAT Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. 31169883 2019
dbSNP: rs12913657
rs12913657
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C1443016
Disease:
Estradiol level result 		C 0.700 GeneticVariation GWASCAT Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. 31169883 2019
dbSNP: rs12438326
rs12438326
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0021704
Disease:
Intelligence 		A 0.700 GeneticVariation GWASCAT Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 29844566 2018
dbSNP: rs11630054
rs11630054
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337428
Disease:
Fibrinogen assay 		0.700 GeneticVariation GWASCAT Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. 28107422 2017
dbSNP: rs12915052
rs12915052
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337428
Disease:
Fibrinogen assay 		0.700 GeneticVariation GWASCAT Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. 28107422 2017
dbSNP: rs12593998
rs12593998
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0200633
Disease:
Neutrophil count (procedure) 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs12593998
rs12593998
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0200641
Disease:
Blood basophil count (lab test) 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs12905525
rs12905525
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0200633
Disease:
Neutrophil count (procedure) 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs12913259
rs12913259
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C0337428
Disease:
Fibrinogen assay 		T 0.700 GeneticVariation GWASCAT A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. 26561523 2016
dbSNP: rs12915708
rs12915708
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C1325327
Disease:
fibrinogen activity 		C 0.700 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013
dbSNP: rs12915708
rs12915708
Entrez Id: 84888
Gene Symbol: SPPL2A
SPPL2A
CUI: C1561955
Disease:
Fibrinogen, CTCAE 		C 0.700 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696 2013