TP63, tumor protein p63, 8626

N. diseases: 816; N. variants: 64
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.840 GeneticVariation BEFREE When analyzed according to histological type, the effects of rs10937405, and rs4488809 at 3q28 on the risk of lung cancer were significant mostly for lung adenocarcinoma. 24466311 2014
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.840 GeneticVariation BEFREE Allele comparison showed that the T allele of rs10937405 was associated with a decreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). 24377560 2014
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.840 GeneticVariation GWASDB A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. 22797724 2012
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.840 GeneticVariation GWASCAT A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. 22797724 2012
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.840 GeneticVariation BEFREE Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. 22367405 2012
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.840 GeneticVariation GWASDB The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10⁻¹²), OR = 1.31). 20871597 2010
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		C 0.840 GeneticVariation GWASCAT The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10⁻¹²), OR = 1.31). 20871597 2010
dbSNP: rs10937405
rs10937405
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder) 		0.840 GeneticVariation BEFREE The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10⁻¹²), OR = 1.31). 20871597 2010
dbSNP: rs121908845
rs121908845
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.810 GeneticVariation BEFREE In addition, we evaluated the conformation and the interaction with Itch-WW2 of a site specific mutant of p63, I549T, that has been reported in both Hay-Wells syndrome and Rapp-Hodgkin syndrome. 20855944 2010
dbSNP: rs121908845
rs121908845
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.810 GeneticVariation UNIPROT Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder. 15200513 2004
dbSNP: rs121908845
rs121908845
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.810 GeneticVariation UNIPROT Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia. 12766194 2003
dbSNP: rs121908845
rs121908845
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.810 GeneticVariation UNIPROT The Rapp-Hodgkin syndrome results from mutations of the TP63 gene. 12939657 2003
dbSNP: rs121908845
rs121908845
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		C 0.810 CausalMutation CLINVAR
dbSNP: rs17505102
rs17505102
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1961102
Disease:
Precursor Cell Lymphoblastic Leukemia Lymphoma 		C 0.800 GeneticVariation GWASCAT Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. 22076464 2012
dbSNP: rs17505102
rs17505102
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1961102
Disease:
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.800 GeneticVariation GWASDB Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. 22076464 2012
dbSNP: rs17505102
rs17505102
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1961102
Disease:
Precursor Cell Lymphoblastic Leukemia Lymphoma 		G 0.800 GeneticVariation GWASCAT Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. 22076464 2012
dbSNP: rs121908847
rs121908847
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1851878
Disease:
OROFACIAL CLEFT 8 		0.800 GeneticVariation UNIPROT A mutation of the p63 gene in non-syndromic cleft lip. 16740912 2006
dbSNP: rs121908840
rs121908840
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.800 GeneticVariation UNIPROT Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder. 15200513 2004
dbSNP: rs121908846
rs121908846
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.800 GeneticVariation UNIPROT Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder. 15200513 2004
dbSNP: rs121908835
rs121908835
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1858562
Disease:
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 		0.800 GeneticVariation UNIPROT EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma. 12838557 2003
dbSNP: rs121908836
rs121908836
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1858562
Disease:
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 		0.800 GeneticVariation UNIPROT EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma. 12838557 2003
dbSNP: rs121908837
rs121908837
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1858562
Disease:
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 		0.800 GeneticVariation UNIPROT EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma. 12838557 2003
dbSNP: rs121908840
rs121908840
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1858562
Disease:
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 		0.800 GeneticVariation UNIPROT EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma. 12838557 2003
dbSNP: rs121908840
rs121908840
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.800 GeneticVariation UNIPROT The Rapp-Hodgkin syndrome results from mutations of the TP63 gene. 12939657 2003
dbSNP: rs121908840
rs121908840
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C1785148
Disease:
RAPP-HODGKIN SYNDROME 		0.800 GeneticVariation UNIPROT Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia. 12766194 2003