SOCS1, suppressor of cytokine signaling 1, 8651

N. diseases: 315; N. variants: 7
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4780355
rs4780355
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0033860
Disease:
Psoriasis
T 0.800 GeneticVariation GWASDB Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. 22482804 2012
dbSNP: rs4780355
rs4780355
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0033860
Disease:
Psoriasis
T 0.800 GeneticVariation GWASCAT Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. 22482804 2012
dbSNP: rs11549428
rs11549428
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0200638
Disease:
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs193778
rs193778
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
G 0.700 GeneticVariation GWASCAT Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. 25751624 2015
dbSNP: rs188754154
rs188754154
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.700 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
dbSNP: rs4780355
rs4780355
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.700 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
dbSNP: rs4780355
rs4780355
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0010346
Disease:
Crohn Disease
T 0.700 GeneticVariation GWASCAT Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. 22482804 2012
dbSNP: rs243330
rs243330
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0028754
Disease:
Obesity
0.020 GeneticVariation BEFREE The polymorphism of the <i>SOCS1</i> gene (rs243330, -1656G>A) is associated with obesity and glucose sensitivity. 31717271 2019
dbSNP: rs243330
rs243330
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0028754
Disease:
Obesity
0.020 GeneticVariation BEFREE In a second study (n = 4625 NGT subjects), significant associations of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. 19215277 2009
dbSNP: rs243330
rs243330
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0004153
Disease:
Atherosclerosis
0.010 GeneticVariation BEFREE Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). 27216615 2016
dbSNP: rs243330
rs243330
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0003850
Disease:
Arteriosclerosis
0.010 GeneticVariation BEFREE Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). 27216615 2016
dbSNP: rs33932899
rs33932899
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0004153
Disease:
Atherosclerosis
0.010 GeneticVariation BEFREE Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). 27216615 2016
dbSNP: rs33932899
rs33932899
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0003850
Disease:
Arteriosclerosis
0.010 GeneticVariation BEFREE Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). 27216615 2016
dbSNP: rs243330
rs243330
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0742343
Disease:
Acute Chest Syndrome
0.010 GeneticVariation BEFREE On the other hand, under co-dominant and heterozygous models, the -1656 G/A (rs243330) SNP was associated with increased risk of ACS (OR=1.47, P(Co-dom)=0.038 and OR=1.50, P(Het)=0.013, respectively). 24997329 2014
dbSNP: rs33932899
rs33932899
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0019163
Disease:
Hepatitis B
0.010 GeneticVariation BEFREE The genotype GC and allele C of rs33932899 were significantly less frequent in HBV patients than controls (pc < 0.001 and p < 0.001, respectively). 24768946 2014
dbSNP: rs33932899
rs33932899
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0742343
Disease:
Acute Chest Syndrome
0.010 GeneticVariation BEFREE Finally, under co-dominant and heterozygous models, the +1125 G/C (rs33932899) SNP was associated with increased risk of ACS (OR=1.54, P(Co-dom)=0.006, OR=1.58, P(Het)=0.012, respectively). 24997329 2014
dbSNP: rs33977706
rs33977706
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0742343
Disease:
Acute Chest Syndrome
0.010 GeneticVariation BEFREE Moreover, under co-dominant, dominant, and heterozygous models, the -820T/G (rs33977706) SNP was associated with increased risk of ACS (OR=1.59, P(Co-dom)=0.03, OR=1.48, P(Dom)=0.028 and OR=1.61, P(Het)=0.01). 24997329 2014
dbSNP: rs33977706
rs33977706
Entrez Id: 8651;116028;105371082
Gene Symbol: SOCS1;RMI2;LOC105371082
SOCS1;RMI2;LOC105371082
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE In a second study (n = 4625 NGT subjects), significant associations of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. 19215277 2009