IRS2, insulin receptor substrate 2, 8660

N. diseases: 152; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2241745
rs2241745
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011847
Disease:
Diabetes 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs2241745
rs2241745
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs2241745
rs2241745
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs2241745
rs2241745
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C4722085
Disease:
Malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation BEFREE IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer. 28212577 2017
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE Stratification analysis of ethnicity found that rs1805097 polymorphism decreased the risk of C</span>RC among Americans. 28212577 2017
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0014556
Disease:
Epilepsy, Temporal Lobe 		0.010 GeneticVariation BEFREE IRS2 1057G/A combined with the INSR His 1085 His polymorphism increased the odds ratio of drug resistance in TLE (P=0.011, OR=2.263, 95% CI: 1.208-4.239). 25458098 2015
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0085207
Disease:
Gestational Diabetes 		0.010 GeneticVariation BEFREE The G1057D polymorphism of insulin receptor substrate-2 associated with gestational diabetes mellitus. 24401133 2014
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE This meta-analysis indicated that IRS2 rs1805097 polymorphism was not associated with colorectal and breast cancer risk. 24497996 2014
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE This meta-analysis indicated that IRS2 rs1805097 polymorphism was not associated with colorectal and breast cancer risk. 24497996 2014
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE However, the evidence for a link between the IRS2 (rs2289046) variant and risk of CRC dependent on the BMI of the subjects, requires confirmation in subsequent studies with greater sample size. 24175768 2013
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE The concurrence of Gly1057Asp polymorphism in IRS-2 with DM is correlated with occurrence of CAD. 23216712 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0010068
Disease:
Coronary heart disease 		0.010 GeneticVariation BEFREE Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population. 23216712 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0010054
Disease:
Coronary Arteriosclerosis 		0.010 GeneticVariation BEFREE Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population. 23216712 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE The concurrence of Gly1057Asp polymorphism in IRS-2 with DM is correlated with occurrence of CAD. 23216712 2012
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0524620
Disease:
Metabolic Syndrome X 		0.010 GeneticVariation BEFREE The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in MetS subjects. 22147666 2012
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0014175
Disease:
Endometriosis 		0.010 GeneticVariation BEFREE These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis. 19878940 2010
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0476089
Disease:
Endometrial Carcinoma 		0.010 GeneticVariation BEFREE These results suggest that IRS-2 G1057D polymorphism may be associated with endometrial cancer. 20184486 2010
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0007103
Disease:
Malignant neoplasm of endometrium 		0.010 GeneticVariation BEFREE These results suggest that IRS-2 G1057D polymorphism may be associated with endometrial cancer. 20184486 2010
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0004096
Disease:
Asthma 		0.010 GeneticVariation BEFREE In asthmatics, IRS2 (rs2289046) was associated with high total IgE levels. 19604268 2009
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE When these three SNPs were examined as a haplotype, only the haplotype that included the G allele of rs2289046 was associated with breast cancer (odds ratio = 0.76, 95% confidence interval = 0.63-0.92 for TGC versus CAT). 18611262 2008
dbSNP: rs2289046
rs2289046
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE When these three SNPs were examined as a haplotype, only the haplotype that included the G allele of rs2289046 was associated with breast cancer (odds ratio = 0.76, 95% confidence interval = 0.63-0.92 for TGC versus CAT). 18611262 2008
dbSNP: rs754204
rs754204
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Three of the 11 SNPs for IRS2 were associated with breast cancer (rs4773082, P = 0.007; rs2289046, P = 0.016; rs754204, P = 0.03). 18611262 2008
dbSNP: rs754204
rs754204
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Three of the 11 SNPs for IRS2 were associated with breast cancer (rs4773082, P = 0.007; rs2289046, P = 0.016; rs754204, P = 0.03). 18611262 2008
dbSNP: rs1805097
rs1805097
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0007102
Disease:
Malignant tumor of colon 		0.010 GeneticVariation BEFREE We evaluated the effect of polymorphisms in four insulin-related genes (G972R in IRS1, G1057D in IRS2, a CA repeat in IGFI and an A/C polymorphism at -202 of IGFBP3) on the risk of microsatellite instability and KRAS2 and TP53 mutations in a population-based set of 1788 cases of colon cancer and 1981 controls. 16448675 2006