Disease: Ulcerative Colitis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1523127
rs1523127
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011
dbSNP: rs1523127
rs1523127
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls. 21245992 2011
dbSNP: rs3814055
rs3814055
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011
dbSNP: rs6785049
rs6785049
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011
dbSNP: rs6785049
rs6785049
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE PXR A7635G (rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease (OR: 1.34, 95% CI: 1.03-1.75 and OR: 2.49, 95% CI: 1.24-5.03, respectively). 21245992 2011
dbSNP: rs3814055
rs3814055
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.020 GeneticVariation BEFREE Three PXR polymorphisms, including the 1 more strongly correlated with IBD risk in the initial study at -25385C/T (rs3814055) and the 6 haplotypes conformed by them, were analyzed in 365 UC and 331 CD patients and compared with 550 ethnically matched controls. 17828778 2007
dbSNP: rs12721602
rs12721602
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011
dbSNP: rs1523128
rs1523128
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011
dbSNP: rs2276707
rs2276707
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE The PXR/NR1I2 SNP rs2276707 was weakly associated with UC susceptibility (P = 0.01; odds ratio [OR] 1.27 [1.06-1.52]). 21830270 2011
dbSNP: rs3814057
rs3814057
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy, unrelated controls was analyzed for eight PXR/NR1I2 single nucleotide polymorphisms (SNPs) (rs12721602 (-25564), rs3814055 (-25385), rs1523128 (-24756), rs1523127 (-24381), rs45610735 = p.Gly36Arg (+106), rs6785049 (+7635), rs2276707 (+8055), and rs3814057 (+11156)). 21830270 2011