|
rs56254331
|
TGFB1;CCDC97
|
Hematuria
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Sequence variants associating with urinary biomarkers.
|
30476138 |
2019 |
|
rs73045269
|
TGFB1;CCDC97
|
Coronary Artery Disease
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
rs2241718
|
TGFB1;CCDC97
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis showed that the C allele of rs1982073 was protective against COPD in Caucasians but not in Asians, whereas there was no association of rs1800469, rs2241712, rs6957, and rs2241718 with COPD.
|
28784933 |
2017 |
|
rs2241718
|
TGFB1;CCDC97
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
|
23267696 |
2012 |
|
rs2241718
|
TGFB1;CCDC97
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array(TM) Technology Platform and then tested the association of four SNPs in TGF-β(1) (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.
|
21556788 |
2011 |
|
rs6957
|
TGFB1;CCDC97
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
No associations with COPD were identified for other polymorphisms evaluated in the present study including rs1800469 (T allele compared with C allele, OR =0.89, 95% CI: 0.77-1.02, <i>P</i>=0.099), rs2241712 (A allele compared with G allele, OR =1.03, 95% CI: 0.89-1.20, <i>P</i>=0.666), rs6957 (A allele compared with G allele, OR =1.14, 95% CI: 0.95-1.36, <i>P</i>=0.160), and rs2241718 (C allele compared with T allele, OR =0.95, 95% CI: 0.79-1.14, <i>P</i>=0.571).
|
28784933 |
2017 |
|
rs6957
|
TGFB1;CCDC97
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
|
23267696 |
2012 |
|
rs2241718
|
TGFB1;CCDC97
|
Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional polymorphism (Q705K; rs35829419) in the NLRP3 gene was associated with interstitial lung fibrosis (p=0.013), and the TGFB1 rs2241718 SNP with visceral pleural fibrosis (VPF) (p=0.044).
|
24142982 |
2014 |
|
rs2241718
|
TGFB1;CCDC97
|
Centriacinar Emphysema
|
|
0.010 |
GeneticVariation |
BEFREE |
The TGFB1 rs2241718 and MMP9 rs3918242 SNPs were associated with centrilobular emphysema (p = 0.022 and p = 0.008), and the TNF rs1800629 SNP with paraseptal emphysema (p = 0.017).
|
23734748 |
2013 |
|
rs2241718
|
TGFB1;CCDC97
|
Paraseptal emphysema
|
|
0.010 |
GeneticVariation |
BEFREE |
The TGFB1 rs2241718 and MMP9 rs3918242 SNPs were associated with centrilobular emphysema (p = 0.022 and p = 0.008), and the TNF rs1800629 SNP with paraseptal emphysema (p = 0.017).
|
23734748 |
2013 |
|
rs2241719
|
TGFB1;CCDC97
|
Temporomandibular Joint Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Interactions were observed between TGFβ1 and IL-8 SNPs: an additional copy of the TGFβ1 rs2241719 minor T allele was associated with twice the odds of TMD+WPT among individuals homozygous for the IL-8 rs4073 major A allele, and half the odds of TMD+WPT among individuals heterozygous for rs4073.
|
22000099 |
2011 |