IL33, interleukin 33, 90865

N. diseases: 487; N. variants: 29
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs12339348
rs12339348
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		0.800 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862 2016
dbSNP: rs10975519
rs10975519
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0014175
Disease:
Endometriosis 		A 0.800 GeneticVariation GWASCAT Genome-wide association study link novel loci to endometriosis. 23472165 2013
dbSNP: rs10975519
rs10975519
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0014175
Disease:
Endometriosis 		A 0.800 GeneticVariation GWASDB Genome-wide association study link novel loci to endometriosis. 23472165 2013
dbSNP: rs12339348
rs12339348
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		T 0.800 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0004096
Disease:
Asthma 		0.800 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs146597587
rs146597587
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0004096
Disease:
Asthma 		G 0.720 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
dbSNP: rs146597587
rs146597587
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0004096
Disease:
Asthma 		0.720 GeneticVariation BEFREE Together these data demonstrate that rs146597587-C is a loss of function mutation and support the hypothesis that IL-33 haploinsufficiency protects against asthma. 28273074 2017
dbSNP: rs146597587
rs146597587
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0004096
Disease:
Asthma 		0.720 GeneticVariation BEFREE This includes a rare splice acceptor variant (rs146597587, MAF = 0.5%) in interleukin 33 (IL33) associated with reduced eosinophil count (P = 2.4x10-23), and lower risk of asthma (P = 2.6x10-7, odds ratio [95% confidence interval] = 0.56 [0.45-0.70]) and allergic rhinitis (P = 4.2x10-4, odds ratio = 0.55 [0.39-0.76]). 28787443 2017
dbSNP: rs7848215
rs7848215
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0004096
Disease:
Asthma 		T 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs7848215
rs7848215
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0004096
Disease:
Asthma 		T 0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
dbSNP: rs7848215
rs7848215
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0264408
Disease:
Childhood asthma 		0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0741260
Disease:
Adult onset asthma 		G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0264408
Disease:
Childhood asthma 		G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs12339348
rs12339348
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
dbSNP: rs12551256
rs12551256
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0264408
Disease:
Childhood asthma 		A 0.700 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
dbSNP: rs10118776
rs10118776
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C0149925
Disease:
Small cell carcinoma of lung 		G 0.700 GeneticVariation GWASCAT Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. 28604730 2017
dbSNP: rs10975488
rs10975488
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C1527304
Disease:
Allergic Reaction 		0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs928413
rs928413
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0264408
Disease:
Childhood asthma 		G 0.700 GeneticVariation GWASCAT A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. 24241537 2014
dbSNP: rs10815393
rs10815393
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10975507
rs10975507
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs17498196
rs17498196
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs17582919
rs17582919
Entrez Id: 90865;107987046
Gene Symbol: IL33;LOC107987046
IL33;LOC107987046
CUI: C1527304
Disease:
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs2066362
rs2066362
Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C1527304
Disease:
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013