DisGeNET - a database of gene-disease associations

KCNB2, potassium voltage-gated channel subfamily B member 2, 9312

N. diseases: 8; N. variants: 14

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs349356

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C1314691
Disease:

Age at menarche

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs7845090

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0518026
Disease:

body fat percentage (physical finding)

0.700

GeneticVariation

GWASCAT

Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

30593698

2019

dbSNP:

rs7845090

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C1305855
Disease:

Body mass index

0.700

GeneticVariation

GWASCAT

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

30239722

2019

dbSNP:

rs16938372

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs1866737

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs1866737

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs2251898

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs2251899

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs877521

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0023467
Disease:

Leukemia, Myelocytic, Acute

0.700

GeneticVariation

GWASCAT

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

27903959

2017

dbSNP:

rs2128158

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASDB

Genome-wide association studies of maximum number of drinks.

23953852

2013

dbSNP:

rs4738296

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0002171
Disease:

Alopecia Areata

0.700

GeneticVariation

GWASDB

Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata.

22027810

2012

dbSNP:

rs16938508

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0030567
Disease:

Parkinson Disease

0.700

GeneticVariation

GWASDB

Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.

21812969

2011

dbSNP:

rs2247572

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0027902
Disease:

Neuropsychological Tests

0.700

GeneticVariation

GWASCAT

Common genetic variation and performance on standardized cognitive tests.

20125193

2010

dbSNP:

rs770305852

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0009402
Disease:

Colorectal Carcinoma

0.700

GeneticVariation

UNIPROT

dbSNP:

rs349358

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0232602
Disease:

Retching

0.010

GeneticVariation

BEFREE

Early PONV occurred in 37%.There was a significant association of the KCNB2 rs349358 SNP with nausea (P = 0.021), retching (P = 0.001), and PONV (P = 0.006).

31077873

2020

dbSNP:

rs349358

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0027497
Disease:

Nausea

0.010

GeneticVariation

BEFREE

Early PONV occurred in 37%.There was a significant association of the KCNB2 rs349358 SNP with nausea (P = 0.021), retching (P = 0.001), and PONV (P = 0.006).

31077873

2020

dbSNP:

rs349358

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0520909
Disease:

Postoperative Nausea and Vomiting

0.010

GeneticVariation

BEFREE

The KCNB2 rs349358 SNP is also an independent PONV predictor and a genetic risk score has a similar impact on PONV susceptibility compared to the Apfel Score.

31077873

2020

dbSNP:

rs17187449

Entrez Id:	9312
Gene Symbol:	KCNB2

KCNB2

CUI:	C0027794
Disease:

Neural Tube Defects

0.010

GeneticVariation

BEFREE

The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)).

23132673

2012