NRXN1, neurexin 1, 9378

N. diseases: 20; N. variants: 26
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1356888
rs1356888
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0023980
Disease:
Longevity 		0.800 GeneticVariation GWASCAT Joint influence of small-effect genetic variants on human longevity. 20834067 2010
dbSNP: rs1356888
rs1356888
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0023980
Disease:
Longevity 		0.800 GeneticVariation GWASDB Joint influence of small-effect genetic variants on human longevity. 20834067 2010
dbSNP: rs1014667
rs1014667
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1519383
Disease:
Smoking Behaviors 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs1014667
rs1014667
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0037369
Disease:
Smoking 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs10490165
rs10490165
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0027404
Disease:
Narcolepsy 		0.700 GeneticVariation GWASDB Genome-wide association database developed in the Japanese Integrated Database Project. 19629137 2009
dbSNP: rs10490175
rs10490175
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0021704
Disease:
Intelligence 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
dbSNP: rs10490175
rs10490175
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease:
Schizophrenia 		0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
dbSNP: rs12618157
rs12618157
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.700 GeneticVariation GWASDB Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. 17362836 2007
dbSNP: rs141864436
rs141864436
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C3894553
Disease:
response to simvastatin 		0.700 GeneticVariation GWASCAT Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. 28736931 2018
dbSNP: rs141864436
rs141864436
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 GeneticVariation GWASCAT Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. 28736931 2018
dbSNP: rs2059308
rs2059308
Entrez Id: 9378;101927089
Gene Symbol: NRXN1;LOC101927089
NRXN1;LOC101927089
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs41522849
rs41522849
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs41522849
rs41522849
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs9636391
rs9636391
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs11681792
rs11681792
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT A genome-wide association study of behavioral disinhibition. 23942779 2013
dbSNP: rs11681792
rs11681792
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0236664
Disease:
Alcohol-Related Disorders 		A 0.700 GeneticVariation GWASCAT A genome-wide association study of behavioral disinhibition. 23942779 2013
dbSNP: rs11681792
rs11681792
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic 		A 0.700 GeneticVariation GWASCAT A genome-wide association study of behavioral disinhibition. 23942779 2013
dbSNP: rs11681792
rs11681792
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0236970
Disease:
Alcohol-Induced Disorders 		A 0.700 GeneticVariation GWASCAT A genome-wide association study of behavioral disinhibition. 23942779 2013
dbSNP: rs1553368900
rs1553368900
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0856975
Disease:
Autistic behavior 		A 0.700 GeneticVariation CLINVAR Molecular and clinical characterization of 25 individuals with exonic deletions of NRXN1 and comprehensive review of the literature. 23533028 2013
dbSNP: rs1553368900
rs1553368900
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0856975
Disease:
Autistic behavior 		A 0.700 GeneticVariation CLINVAR Phenotypic spectrum and genotype-phenotype correlations of NRXN1 exon deletions. 22617343 2012
dbSNP: rs199546979
rs199546979
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0028754
Disease:
Obesity 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs2139629
rs2139629
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs6750228
rs6750228
Entrez Id: 9378;730100
Gene Symbol: NRXN1;LOC730100
NRXN1;LOC730100
CUI: C0001925
Disease:
Albuminuria 		A 0.700 GeneticVariation GWASCAT Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. 30220432 2018
dbSNP: rs6754640
rs6754640
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0039474
Disease:
Temperament 		A 0.700 GeneticVariation GWASDB A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. 22832960 2012
dbSNP: rs7603103
rs7603103
Entrez Id: 9378;730100
Gene Symbol: NRXN1;LOC730100
NRXN1;LOC730100
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018