CDK1, cyclin dependent kinase 1, 983

N. diseases: 214; N. variants: 8
Disease: Malignant neoplasm of breast ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1871446
rs1871446
Entrez Id: 983
Gene Symbol: CDK1
CDK1
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE For CDK1, rs2448343 and rs1871446 were significantly associated with decreased BC risk under dominant models, so was the haplotype ATATT. 24386390 2013
dbSNP: rs2448343
rs2448343
Entrez Id: 983
Gene Symbol: CDK1
CDK1
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Using stratified association analysis, we found that women with the heterozygotes or minor allele homozygotes of rs2448343 had much less BC susceptibility among women with BMI<23. 24386390 2013
dbSNP: rs3213048
rs3213048
Entrez Id: 983
Gene Symbol: CDK1
CDK1
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE In CDK1, three closely located SNPs, rs2448343, rs3213048 and rs3213067, were significantly associated with tumor's PR status: the heterozygotes of rs2448343 were associated with PR-positive tumors, while the minor allele homozygotes of rs3213048 and heterozygotes of rs3213067 were associated with PR-negative BC tumors. 24386390 2013
dbSNP: rs3213067
rs3213067
Entrez Id: 983
Gene Symbol: CDK1
CDK1
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE In CDK1, three closely located SNPs, rs2448343, rs3213048 and rs3213067, were significantly associated with tumor's PR status: the heterozygotes of rs2448343 were associated with PR-positive tumors, while the minor allele homozygotes of rs3213048 and heterozygotes of rs3213067 were associated with PR-negative BC tumors. 24386390 2013