There is an association between the <i>SIRT2-C/T</i> genotype (rs10410544) (50.92%) and AD susceptibility in the <i>APOEε4</i>-negative population (<i>SIRT2-C/C</i>, 34.72%; <i>SIRT2-T/T</i> 14.36%).
A number of genetic variants have previously been identified and associated with the risk of Alzheimer's disease (AD), including rs10838725 in CELF1, rs28834970 in PTK2B, rs17125944 in FERMT2, and rs10410544 in SIRT2 based on genome-wide association studies.
Five SNPs related to SIRT1, rs3740051, rs7895833, rs7069102, rs2273773, and rs4746720 and two SNPs related to SIRT2, rs10410544, and rs45592833 did not show an association with PD risk in this study.