|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of this study was to investigate the association of ANGPTL4 variants (E40K and T266M) with triglyceride levels and with cardiovascular risk factors, such as metabolic syndrome (MetS) and obesity in type 2 diabetic Tunisian population.
|
27004807 |
2016 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D.
|
21714923 |
2011 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
ANGPTL4 T266M variant is associated with reduced cancer invasiveness.
|
28641978 |
2017 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
ANGPTL4 T266M variant is associated with reduced cancer invasiveness.
|
28641978 |
2017 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings may explain the differences in the tumor characteristics and energy metabolism observed with the cANGPTL4 T266M mutation compared to tumors without the mutation.
|
28641978 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the effect of the tagging single nucleotide polymorphisms (SNPs) rs1044250 (T266M) and rs116843064 (E40K) with triglyceride (TG) levels and CAD risk factors in a cohort of 220 patients undergoing coronary angiography for the evaluation of stable CAD, all of whom had (type 2 diabetes) T2D and were at least overweight.
|
27004807 |
2016 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
So, T266M and E40K polymorphism predicts cardiovascular disease risk in Type 2 diabetic Tunisian population.
|
27004807 |
2016 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to investigate the association of ANGPTL4 variants (E40K and T266M) with triglyceride levels and with cardiovascular risk factors, such as metabolic syndrome (MetS) and obesity in type 2 diabetic Tunisian population.
|
27004807 |
2016 |
|
Liver neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In human embryonic kidney 293 and human hepatoma 7 cells compared with wild type, E40K and T266M showed significantly altered synthesis and secretion, respectively.
|
20829508 |
2010 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Circulating Angptl4 levels may not influence TG levels or CHD risk for the following reasons: (1) Angptl4 levels were not correlated with TGs; (2) T266M, although associated with Angptl4 levels, showed no association with plasma TGs; and (3) TG-lowering E40K did not influence Angptl4 levels.
|
20829508 |
2010 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In human embryonic kidney 293 and human hepatoma 7 cells compared with wild type, E40K and T266M showed significantly altered synthesis and secretion, respectively.
|
20829508 |
2010 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped 629 subjects with and without a family history of diabetes for the 4 single nucleotide polymorphisms (SNPs) rs4076317, rs2278236, rs1044250, and rs11672433 and performed correlational analyses with metabolic traits.
|
18442626 |
2008 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped 629 subjects with and without a family history of diabetes for the 4 single nucleotide polymorphisms (SNPs) rs4076317, rs2278236, rs1044250, and rs11672433 and performed correlational analyses with metabolic traits.
|
18442626 |
2008 |