Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was conducted to assess the role of the C3435T polymorphism in drug-resistance in epilepsy.
|
24794827 |
2014 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
For a single gene test, it was demonstrated that 3435C>T in the ABCB1 gene had a significant effect on epilepsy treatment responses, but polymorphisms in the NR1I2 gene did not.
|
17924830 |
2007 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a significant association was observed between ABCB1 (C3435T) rs1045642 and risk of having epilepsy (MTLE-HS and JME pooled cohort; genotypic p-value = 0.0002; allelic p-value = 0.004).
|
24586633 |
2014 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, the authors investigated the association between the MDR1 gene polymorphisms, C3435T and G2677AT, and drug resistance epilepsy by using polymerase chain reaction/restriction fragment length polymorphism and pyrosequencing methods in a group of 39 patients with drug-resistant epilepsy and 92 controls.
|
20448249 |
2010 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population.
|
21420937 |
2011 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.
|
18436433 |
2008 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34).
|
20491876 |
2010 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and eight patients with drug-responsive epilepsy, 63 patients with drug-resistant epilepsy, and 219 control migraine subjects were studied, but the analysis for C3435T allele showed no significant association between the CC genotype and the multidrug-resistant epilepsy.
|
16542858 |
2006 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
|
21388909 |
2011 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the ABCB1 rs3789243 C>T, C1236T, G2677T/A, rs6949448 C>T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
|
21530324 |
2011 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic drugs.
|
19167193 |
2009 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association.
|
16857572 |
2006 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 3435C>T polymorphism and type of epilepsy were associated with response to PB.
|
25846690 |
2015 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ABCB1 T-129C, C1236T, G2677T/A and C3435T polymorphisms were genotyped in 210 Japanese epileptics who had been prescribed AEDs, including CBZ, for longer than 2 years.
|
16753003 |
2006 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
|
25223475 |
2014 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy.
|
24213830 |
2014 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in our population.
|
29198163 |
2018 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
|
23984379 |
2013 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy.
|
25458099 |
2015 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that C3435T is unlikely to be a marker for epilepsy multidrug resistance.
|
17460550 |
2007 |