rs1048412, ZNRD1

N. diseases: 1
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Human immunodeficiency virus (HIV) II infection category B1
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
0.010 GeneticVariation BEFREE Genetic association analysis found a strong statistically significant correlation with the LTNP phenotype (single-nucleotide polymorphism rs1048412; P = .0004), independently of HLA-A10 influence. siRNA-based functional analysis showed that ZNRD1 down-regulation by siRNA or shRNA impaired HIV-1 replication at the transcription level in both lymphoid and nonlymphoid cells. 20192730 2010