|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
|
21697764 |
2011 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).
|
22534784 |
2012 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We further showed that these two genetic variants on 15q24-25.1 independently influence lung cancer risk (rs1051730: P = 4.42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92).
|
20395203 |
2010 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Smoking behavior and COPD are mediators of the association between the single nucleotide polymorphism (SNP) rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided).
|
20554942 |
2010 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the associations between the nicotinic acetylcholine receptor polymorphism (rs1051730) on chromosome 15q25 marking the gene cluster CHRNA3-CHRNB4-CHRNA5, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases in the general population.
|
21646606 |
2011 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cox-proportional hazards models were used to determine the correlation between rs1051730 and incidence of first COPD, tobacco-related cancer, other cancer and cardiovascular disease (CVD), and total mortality due to these causes, during approximately 14 years of follow-up.
|
26689306 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The authors applied a rigorous statistical approach, mediation analysis, to examine the mediating effect of smoking behavior and self-reported, physician-diagnosed emphysema (chronic obstructive pulmonary disease [COPD]) on the relation between the CHRNA5-A3 region genetic variant rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two SNPs (rs6495309 and rs1051730) located in nicotinic acetylcholine receptor alpha 3 (CHRNA3) gene were genotyped in 1511 patients with COPD, 1559 lung cancer cases and 1677 controls in southern and eastern Chinese populations.
|
23056235 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the LEUVEN cohort, rs1051730 AA-carriers and rs8034191 GG-carriers had a two-fold increased risk to suffer from COPD GOLD IV (OR 2.29, 95% confidence interval [CI] = 1.11-4.75; p = 0.025 and OR = 2.42, 95% [CI] = 1.18-4.95; p = 0.016, respectively).
|
23349703 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we compared genetic variants influencing the effect of smoking on COPD, that is, the effect of the well-known splicing defect polymorphism, CYP3A5*3 (rs776746), identified before genome-wide association studies, with the genome-wide association studies identified CHRNA3 (rs1051730) polymorphism on the risk of decreased lung function and COPD.
|
24535486 |
2014 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study showed the association of rs13180, rs16969968 and rs1051730 with COPD and lung function in Tatar population from Russia.
|
28474623 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our analysis revealed that effects of two linked variants (rs1051730 and rs8034191) in the AGPHD1/CHRNA3 cluster on COPD development are significantly, yet not entirely, mediated by the smoking-related phenotypes.
|
23299987 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Cox-proportional hazards models were used to determine the correlation between rs1051730 and incidence of first COPD, tobacco-related cancer, other cancer and cardiovascular disease (CVD), and total mortality due to these causes, during approximately 14 years of follow-up.
|
26689306 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity.
|
22441734 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Four SNPs (rs1964678, rs12593229, rs965604 and rs13180) in IREB2 were associated with forced expiratory volume in 1 s (FEV(1))% predicted and three SNPs (rs16969968, rs8034191 and rs1051730) in CHRNA3/5 were both associated with FEV(1)% predicted and FEV(1)/FVC in COPD cases (P range 0.007-0.050).
|
22914670 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
|
21921092 |
2011 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings suggest that rs1051730 in CHRNA is a susceptibility variant for COPD, in terms of both airway obstruction and parenchyma destruction.
|
22176972 |
2011 |
|
Chronic Obstructive Airway Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although rs1051730 and rs6495309 were shown to be independent risk factors for COPD, validation studies should be performed.
|
25051068 |
2014 |