rs1059513, NAB2;STAT6

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Adult onset asthma
CUI: C0741260
Disease: Adult onset asthma
0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Asthma
CUI: C0004096
Disease: Asthma
0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Asthma
CUI: C0004096
Disease: Asthma
0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
Leukemia, Myelocytic, Acute
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
Eosinophil count procedure
CUI: C0200638
Disease: Eosinophil count procedure
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Blood basophil count (lab test)
CUI: C0200641
Disease: Blood basophil count (lab test)
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Allergic sensitization
CUI: C3662483
Disease: Allergic sensitization
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. 23817571 2013
Eosinophilic esophagitis
CUI: C0341106
Disease: Eosinophilic esophagitis
0.010 GeneticVariation BEFREE Carriage of STAT6 allelic variant rs1059513 predicts PPI-REE (OR [95% CI] = 6.16 [1.44, 26.4], P = 0.028), whereas carriage of STAT6 rs324011 synergizes with CYP2C1917 to predict PPI-nonresponsive EoE (rs324011 OR [95% CI] = 5.56 [1.33, 20.72], P = 0.022; CYP2C1917 OR [95% CI] = 8.19[1.42, 50.57], P = 0.023). 31490856 2019
IgE-mediated food allergy
CUI: C4554344
Disease: IgE-mediated food allergy
0.010 GeneticVariation BEFREE The A alleles of both SNPs were associated with food allergy (P = .036 and P = .013 for rs324015 and rs1059513, respectively). 29457221 2018
Eczema
CUI: C0013595
Disease: Eczema
0.010 GeneticVariation BEFREE Our study adds to the current knowledge of genetic susceptibility by demonstrating for the first time an interactive effect between SNPs in IL13 (rs20541) and STAT6 (rs1059513) on the occurrence of eczema in two independent samples. 23815671 2013
Glioma
CUI: C0017638
Disease: Glioma
0.010 GeneticVariation BEFREE This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015. 21196282 2011