|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD.
|
27647805 |
2017 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Complement factor H polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, RPE damage, and visual decline.
|
28913923 |
2017 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
CFH Y402H SNP might be protective for AMD in the Turkish population.
|
27404493 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphism rs1061170/Y402H might be a genetic predictor of treatment response to anti-VEGF therapy in AMD patients.
|
27151934 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Odds ratios, especially for the main risk polymorphisms in ARMS2 (rs10490924) and CFH (rs1061170), gained with increasing disease severity and bilateralism (exemplarily: rs1061170: unilateral early AMD: OR = 1.18; bilateral early AMD: OR = 1.20; unilateral intermediate AMD: OR = 1.28; bilateral intermediate AMD: OR = 1.39, unilateral geographic atrophy (GA): OR = 1.50; bilateral GA: OR = 1.71).
|
27257685 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis.
|
27269047 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the association of extramacular drusen (EMD) with age-related macular degeneration (AMD) and with complement factor H (CFH rs1061170) and age-related maculopathy susceptibility 2 (ARMS2 rs10490924) polymorphisms in individuals with and without AMD.
|
26614632 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Based on this, we conclude that liver-kidney yin-deficiency AMD is associated with the C allele and TC and CC genotypes of the CFH Y402H polymorphism.
|
27706724 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
AMD individuals who had at least one copy of the C allele of rs1061170 had an increased risk of disease compared with cases with the T allele.
|
25612476 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
AG genotype of CCL2-2518 in combination with TT genotype of CFH Y402H showed significant protective effect against AMD.
|
27316788 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that CFH rs1061170 and rs1410996 polymorphisms were associated with AMD risk, both of which demonstrated a higher susceptibility to AMD, especially to nAMD.
|
26727378 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results suggest that a genetic predisposition to AMD conferred by the CFH Y402H variant limits the benefit provided by DHA supplementation.
|
26132079 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygous carriers of the Y402H risk variant in the complement factor H (CFH) gene developed neovascular AMD 2.8 (95% CI, 0.5-5.0) years earlier (P = .02).
|
25695752 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
No associations appeared between HIF1A SNPs and AMD, which were studied here for the first time; however, polymorphism rs1061170 of the CFH gene is associated with AMD in our population.
|
24995509 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Risk alleles of three SNPs, rs1061170 (CFH), rs1410996 (CFH), and rs10490924 (ARMS2) were found to be significantly associated with the AMD case/control status as defined by the algorithm.
|
26255974 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk variants in rs1061170 (CFH) and rs11200638 (HTRA1).
|
25627090 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Female sex and the presence of both risk alleles of CFH-rs1061170 or ARMS2-rs10490924 were independently associated with early AMD incidence, whereas current smoking and presence of ≥1 risk allele of CFH-rs1061170 or ARMS2-rs10490924 were associated with late AMD incidence.
|
26383995 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present study confirmed the association between CFH Y402H SNP and wet AMD in the Greek population (OR=1.77, p=0.002).
|
25811666 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Younger age of exudative AMD onset was associated with the homozygous AA genotype of IL-8 rs4073 (p = 0.009, Mann-Whitney U-test), CC genotype of CFH rs1061170 (p = 0.016), TT genotype of ARMS2 rs10490924 (p = 0.001) and with current smoking (p = 0.002).
|
26154559 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, pharmacogenetics of CFH Y402H polymorphism may play a role in response to anti-VEGF treatment for neovascular AMD, especially for Caucasians.
|
26411831 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study found significant association of SNPs rs529825, rs800292, rs203674 and rs1061170 in the CFH gene with susceptibility to AMD.
|
26152901 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjusting for CFH Y402H genotype, age, sex and smoking history, the level of sTNFRII remained a significant predictor for prevalence of AMD with odds ratios at 3.0 in the middle and 3.6 in the highest tertiles.
|
25363549 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A 6.7-fold increased odds of AMD (95% CI, 1.6-28.2) was observed among women with deficient vitamin D status (25[OH]D <12 ng/mL) and 2 risk alleles for CFH Y402H (SI for additive interaction, 1.4; 95% CI, 1.1-1.7; P for multiplicative interaction = .25).
|
26312598 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results revealed that CFH polymorphisms I62V and Y402H might be associated with the susceptibility to AMD in Chinese population.
|
26045838 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, among pseudophakic/aphakic individuals, the CFH Y402H risk genotypes were significantly associated with higher odds of early AMD, with an OR of 1.57 (95% CI: 1.07-2.29) for GA genotype and 2.40 (95% CI: 1.25-4.61) for AA genotype, compared to those with GG genotype.
|
25786237 |
2015 |