|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Associations between functional TNFR2 196 M/R polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
|
24777778 |
2014 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.
|
16871413 |
2006 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
The results of the present study support the hypothesis that there is an association between the TNFRII 196 M/R gene polymorphism and the functional severity of early RA.
|
15022314 |
2004 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
To assess the effect of a functional polymorphism (676T>G, M196R) in the tumour necrosis factor receptor super family 1b (TNFSF1b) gene on disease activity, radiological joint damage and response to infliximab and adalimumab treatment in patients with rheumatoid arthritis (RA).
|
18385279 |
2008 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis.
|
15252214 |
2004 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy.
|
18565259 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, no skewed distribution of TNFR2 196 R/M polymorphism was found in Korean patients with SLE compared with healthy controls.
|
11600223 |
2001 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Thus, among the non-synonymous cSNPs, only nt587 (T-->G) (M196R) was found to be significantly associated with SLE in Japanese.
|
11197692 |
2000 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings suggest that the association between cigarette smoking and SLE could be differentiated by the TNFRSF1B rs1061622 T allele among female Japanese subjects.
|
19684152 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conducted a meta-analysis of studies on the association between TNFRSF1B rs1061622 T/G polymorphism or TNFRSF1A A/G rs767455 polymorphism and non-responsiveness to anti-TNF therapy in autoimmune diseases.
|
26071216 |
2015 |
|
Hyperandrogenism
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.
|
12161545 |
2002 |
|
Hyperandrogenism
|
|
0.020 |
GeneticVariation
|
BEFREE |
The opposite behaviors in terms of clinical expressivity detected for CAPN-UCSNP44 and TNFR2-M196R rare variants suggest these variants to be sensitizing and protective factors respectively in adrenal hyperandrogenism.
|
19039234 |
2009 |
|
Paranoid Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia.
|
20842464 |
2011 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, we report a significant association between the TNFRSF1B p.M196R variant and the risk for psoriasis and the response to treatment with anti-TNF or anti-Il-12/Il-23.
|
25537528 |
2015 |
|
Paranoid Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the association of the three single nucleotide polymorphisms (rs3397, rs1061622, and rs1061624) in <i>TNFR2</i> gene with a predisposition to and psychopathology of paranoid schizophrenia in Caucasian population.
|
30254506 |
2018 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
Acne Vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.
|
20861605 |
2010 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses.
|
29915336 |
2018 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigate the clinical association of tumor necrosis factor receptor 2 (TNFR2) M196R polymorphism with rheumatoid arthritis (RA) and knee osteoarthritis (OA).
|
16871413 |
2006 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |