|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the exact biological function for this SNP remains to be explored, our findings suggest a possible role of TNFRSF1B +676 T>G (rs1061622) in the prognosis of NSCLC.
|
21995493 |
2011 |
|
Paranoid Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia.
|
20842464 |
2011 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Associations between functional TNFR2 196 M/R polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
|
24777778 |
2014 |
|
Infection by Wuchereria bancrofti
|
|
0.010 |
GeneticVariation
|
BEFREE |
ET-1 (Ala288Ser) and TNFR-II (Met196Arg) polymorphisms are associated with development of one or the other form of chronic disease in bancroftian filariasis.
|
21673044 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, no skewed distribution of TNFR2 196 R/M polymorphism was found in Korean patients with SLE compared with healthy controls.
|
11600223 |
2001 |
|
Hyperandrogenism
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.
|
12161545 |
2002 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.
|
12161545 |
2002 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, we report a significant association between the TNFRSF1B p.M196R variant and the risk for psoriasis and the response to treatment with anti-TNF or anti-Il-12/Il-23.
|
25537528 |
2015 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we investigated genetic polymorphisms of TNF alpha -308 G/A, TNF beta +252 G/A, and TNFR2 196 R/M in 94 Korean BD patients and age- and sex-matched healthy controls to investigate the role of TNF and TNF receptor polymorphisms in BD.
|
12770792 |
2003 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy.
|
18565259 |
2008 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
Mental Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Vasculitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses.
|
29915336 |
2018 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only rs1061622 was significantly associated with long-term efficacy of etanercept: the TG genotype of rs1061622 worsened ASAS20 and ASAS40 responses at 12 months (P = .021 and .041, respectively).The results suggest that TNFRSF1A and TNFRSF1B polymorphisms were associated with susceptibility, severity, and the long-term therapeutic efficacy of etanercept of patients with AS.
|
30075559 |
2018 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our case-control study (401 patients and 657 controls) revealed that the genetic variants of rs3397, rs1061622, and rs1061624 in the <i>TNFR2</i> gene are associated with a higher risk of developing schizophrenia and more severe course in men.
|
30254506 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings suggest that the association between cigarette smoking and SLE could be differentiated by the TNFRSF1B rs1061622 T allele among female Japanese subjects.
|
19684152 |
2009 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
|
25010932 |
2014 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven polymorphisms of caspase 9 (rs2308941)C-->T and DOK2(rs2242241) T-->G, 6 of polymorphisms of EGFL3 (rs947345)A -->G, caspase 9 ( rs2308938) C-->G and PHGDH(rs1801955)T-->A, 5 of polymorphisms of E2F2(rs3218170) G-->A,4 of polymorphisms of MUTYH(rs1140507)T-->C and BNIP3L(rs1055806)G-->T, and 1 of polymorphism of TNFRSF1B (rs1061622)T-->G were detected by the chip in the tissues of 10 HCC.
|
16109524 |
2005 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |