Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Isoform-specific increases in NRG3 are observed in schizophrenia and associated with rs10748842, a NRG3 risk polymorphism, suggesting NRG3 transcriptional dysregulation as a molecular mechanism of risk.
|
27771971 |
2017 |
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Here, we report an association between rs10748842 and PFC physiology as measured by functional magnetic resonance imaging of human working memory performance, where a convincing link between increased genetic risk for schizophrenia and increased activation in some PFC areas has been established.
|
24431462 |
2014 |
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Previous fine mapping of the 10q22-23 locus in schizophrenia identified genome-wide significant association between delusion severity and polymorphisms in intron 1 of NRG3 (rs10883866, rs10748842, and rs6584400).
|
20713722 |
2010 |
Chronic schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
Cognition Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
Hirschsprung Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the effects of RET (rs2506030 and rs2435357), NRG1 (rs2439302, rs16879552 and rs7835688) and NRG3 (rs10748842, rs10883866 and rs6584400) polymorphisms in a Chinese population with HSCR.
|
28256518 |
2017 |
Mood Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Principally, the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk genotype and are increased in mood disorders further implicates a molecular mechanism of psychiatric risk at the NRG3 locus and identifies a potential developmental role for NRG3 in bipolar disorder and major depression.
|
27771971 |
2017 |
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Principally, the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk genotype and are increased in mood disorders further implicates a molecular mechanism of psychiatric risk at the NRG3 locus and identifies a potential developmental role for NRG3 in bipolar disorder and major depression.
|
27771971 |
2017 |
Unipolar Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
Principally, the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk genotype and are increased in mood disorders further implicates a molecular mechanism of psychiatric risk at the NRG3 locus and identifies a potential developmental role for NRG3 in bipolar disorder and major depression.
|
27771971 |
2017 |