|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 9p21 SNP (rs10757274) and multiple risk markers were measured in the Atherosclerosis Risk in Communities Study, and incident coronary disease events were ascertained.
|
22935634 |
2012 |
|
recurrent myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
TexGen registry participants with ACS (n=2,067) or CABG (n=1,176) were evaluated, to assess whether 9p21 SNPs (rs1333049, rs2383206, rs10757278, rs10757274) were associated with recurrent MI (primary outcome), recurrent revascularization, or death (secondary outcomes) at approximately 3.2 years of follow-up.
|
22322877 |
2012 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 9p21 SNP (rs10757274) and multiple risk markers were measured in the Atherosclerosis Risk in Communities Study, and incident coronary disease events were ascertained.
|
22935634 |
2012 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analysed the relationship between the rs10757274 variant on chromosome 9 and risk of the acute coronary syndrome (ACS) in Czech population.
|
23249639 |
2012 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of diabetes was lower in patients carrying GG genotype for rs10757274, rs2383206 and rs10757278 (29.4%, 32.8%, 32.0%) compared to patients carrying AA or AG genotypes (49.1% and 39.2%, p = 0.01; 52.4% and 40.1%, p = 0.01; 47.8% and 37.9%, p = 0.04; respectively).
|
22856518 |
2012 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of diabetes was lower in patients carrying GG genotype for rs10757274, rs2383206 and rs10757278 (29.4%, 32.8%, 32.0%) compared to patients carrying AA or AG genotypes (49.1% and 39.2%, p = 0.01; 52.4% and 40.1%, p = 0.01; 47.8% and 37.9%, p = 0.04; respectively).
|
22856518 |
2012 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined associations of rs10757274 and rs2383206 polymorphisms with incident HF through 2005 and ischaemic stroke through 2004, and with prevalent carotid atherosclerosis and peripheral artery disease (PAD) at baseline.
|
19329499 |
2009 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1.50) for rs10757274 on chromosome 9p21.
|
19752551 |
2009 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (< 50 years) and older CVD patients.
|
26772723 |
2016 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population.
|
25592106 |
2015 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Peripheral Arterial Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
TexGen registry participants with ACS (n=2,067) or CABG (n=1,176) were evaluated, to assess whether 9p21 SNPs (rs1333049, rs2383206, rs10757278, rs10757274) were associated with recurrent MI (primary outcome), recurrent revascularization, or death (secondary outcomes) at approximately 3.2 years of follow-up.
|
22322877 |
2012 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, rs10757274 polymorphism was not associated with the classical risk factors either in control population or in ACS patients.
|
23249639 |
2012 |
|
Peripheral Arterial Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined associations of rs10757274 and rs2383206 polymorphisms with incident HF through 2005 and ischaemic stroke through 2004, and with prevalent carotid atherosclerosis and peripheral artery disease (PAD) at baseline.
|
19329499 |
2009 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Study subjects were followed up for development of SCD, and genotypes for rs10757274 were determined for 492 sudden and/or arrhythmic deaths and 1460 controls matched for age, sex, cohort, history of cardiovascular disease, and follow-up time.
|
19901189 |
2009 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Further subgroup analyses by ethnicity revealed that rs2383206, rs10757274 and rs10757278 variants were all significantly correlated with an increased risk of IS in Asians.
|
30962266 |
2019 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Loci rs2383206 and rs10757274 may increase susceptibility to IS.
|
31055994 |
2019 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The variants rs2383206 and rs10757274 were not associated with hypertension.
|
29791233 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Lastly, we detected a correlation between GG, GA, and AG haplotypes in block 1 (rs10757274, rs2383207) and GC and AG haplotypes in block 2 (rs10757278, rs1333049) and HT.
|
26944720 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, T2DM is likely to have an interaction with CDKN2A/B (rs10757274) that contributes to the risk of MI.
|
25430018 |
2014 |