|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).
|
27741513 |
2016 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population.
|
25592106 |
2015 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites.
|
20031596 |
2009 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although overall, rs10757274 did not add substantially to the usefulness of the FRS for predicting future events, it did improve reclassification of CHD risk, and thus may have clinical utility.
|
18250146 |
2008 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively).
|
18957718 |
2008 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed the associations between four polymorphisms and CHD, the rs1151640 polymorphism in the olfactory receptor family 13 subfamily G member 1 (OR13G1) gene (HR 1.14, 95% CI 1.01-1.28, P = 0.03), the rs11881940 polymorphism in the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1) gene (HR 1.27, 95% CI 1.07-1.51, P = 0.007), the rs3746731 polymorphism in the complement component 1 q subcomponent receptor 1 (CD93) gene (HR 1.26, 95% CI 1.06-1.49, P = 0.01), and the rs10757274 polymorphism near the cyclin-dependent kinase N2A and N2B (CDKN2A and CDKN2B) genes (HR 1.39, 95% CI 1.15-1.69, P < 0.001).
|
18599554 |
2008 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274.
|
18925945 |
2008 |
|
Aortic Aneurysm, Abdominal
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).
|
23727086 |
2013 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study.
|
23394302 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, rs2383206, rs10757274, and rs10757278 polymorphisms were also significantly correlated with the likelihood of CAD in Caucasians and West Asians.
|
30387168 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
For rs10757274 and rs10757278, the GG genotype indicated a significant 3-fold and 4-fold increased risk of CAD (p<0.0001,respectively).
|
31472045 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses showed that rs1333040, rs1333049 and rs2383207 polymorphisms were significantly correlated with the risk of CAD in East Asians, rs2383206 and rs10757274 polymorphisms were significantly correlated with the risk of CAD in West Asians, while rs2383206, rs10757274 and rs10757278 polymorphisms were significantly correlated with the risk of CAD in Caucasians.
|
30814313 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results for the association between the genotype on the basis of rs10757274 showed a strong association between the GG genotype and the occurrence of CAD (OR: 9.603; 95% CI: 5.746-16.05).
|
25592106 |
2015 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs10757274 genotype was significantly associated with CAD (p = 0.003) and GG genotype carriers had a higher level of ANRIL exon 1-5 expression compared among three genotypes (p = 0.009).
|
23091611 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant.
|
22430189 |
2012 |