|
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The DRD2 rs1076560 polymorphism and schizophrenia-related intermediate phenotypes: A systematic review and meta-analysis.
|
28104410 |
2017 |
|
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this work implicates rs1076560(T) as one possible risk factor for schizophrenia in the Han Chinese population, and suggests molecular mechanisms by which it may exert such influence.
|
26347318 |
2016 |
|
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Moreover, we found that rs1076560 T carrier/rs6314 CC individuals had better responses to antipsychotic treatment in two independent samples of patients with schizophrenia (n=63 and n=54, respectively), consistent with the previously reported separate effects of these genotypes.
|
25563748 |
2015 |
|
Schizophrenia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The association between rs1076560 and schizophrenia was replicated in the second stage.
|
22569179 |
2012 |
|
Nonorganic psychosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings did not provide evidence of a possible role of COMT Val<sup>158</sup>Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis.
|
29653893 |
2019 |
|
Psychotic Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings did not provide evidence of a possible role of COMT Val<sup>158</sup>Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis.
|
29653893 |
2019 |
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.
|
29249680 |
2018 |
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms, rs2283265 and rs1076560, in the dopamine D2 receptor gene (DRD2) were found to be significantly associated with a favourable peak response to rasagiline at 12 weeks in early Parkinson's disease after controlling for multiple testing.
|
27190009 |
2016 |
|
Psychotic Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Thus, variation of the DRD2, rs1076560, genotype may modulate the psychosis-inducing effect of cannabis use.
|
25829376 |
2015 |
|
Nonorganic psychosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Thus, variation of the DRD2, rs1076560, genotype may modulate the psychosis-inducing effect of cannabis use.
|
25829376 |
2015 |
|
Cocaine Abuse
|
|
0.020 |
GeneticVariation
|
BEFREE |
One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) (n = 336) and African American (AA) (n = 1034) cocaine addicts and EA (n = 656) and AA (n = 668) controls.
|
24359476 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms: D2 (rs1076560), Tag1D (rs1800498), Tag1B (rs1079597) located in dopamine receptor 2 DRD2 gene and its role in alcohol dependence.
|
25380208 |
2014 |
|
Cocaine Abuse
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results confirm the role of rs2283265/rs1076560 in D2 alternative splicing and support a strong role in susceptibility to cocaine abuse.
|
21150907 |
2011 |
|
Alcoholic Intoxication, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
These data identify SNP rs1076560 as a potentially important variable in the development of alcoholism.
|
17196743 |
2007 |
|
Heroin Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither rs1076560 nor rs2283265 significantly associated with heroin addiction.
|
31025317 |
2019 |
|
Substance Use Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study is the first study to determine the allele frequency and the genetic association of the <i>DRD2</i> rs1076560 SNP and <i>OPRM1</i> rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE).
|
29881439 |
2018 |
|
Cannabis use
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, variation of the DRD2, rs1076560, genotype may modulate the psychosis-inducing effect of cannabis use.
|
25829376 |
2015 |
|
Drug Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
When both opioid-addicted ancestral samples were combined, rs1076560 was significantly associated with increased risk for drug dependence (p = 0.0038, OR = 1.29).
|
24359476 |
2014 |
|
Opiate Addiction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also analysed the role of rs1076560 in opioid dependence by genotyping EA (n = 1041) and AA (n = 284) opioid addicts. rs1076560 was found to be nominally associated with opioid dependence in EAs (p = 0.02, OR = 1.27) and AAs (p = 0.03, OR = 1.43).
|
24359476 |
2014 |