|
Leukemia, Myelocytic, Acute
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The PPARγ rs10865710 C allele carriers were found to be less likely to suffer from VPA-induced obesity compared with GG genotype carriers (OR, 0.04; 95%CI, 0.01-0.12; P < 0.001).
|
29984389 |
2018 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
CAD susceptibility was higher in those with homozygous mutant of rs10865710, rs1805192 and rs4646903 than those with wild-type homozygotes, OR (95%CI) were 1.47 (1.15-1.92), 1.69 (1.27-2.09) and 1.72 (1.35-2.32), respectively.
|
28415751 |
2017 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations were found between rs10766197 of CYP2R1, rs7041 and rs4588 of CG, rs4646536 of CYP27B1, rs2228570, rs7975232, and rs1544410 of VDR, as well as rs1805192 and rs10865710 of PPAR and susceptibility to and prognosis of childhood bronchial asthma, providing novel targets for treating the disorder.
|
28590769 |
2017 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found a significant association between genotypes of variants in rs10865710 and rs1805192 with increased CVD risk and a potential gene-gene interaction between rs1805192 and smoking.
|
26475999 |
2016 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10865710 polymorphism in the PPARγ gene might be used to assess the risk of sepsis and multiple organ dysfunction syndrome (MODS) in trauma patients.
|
27023591 |
2016 |
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10865710 polymorphism in the PPARγ gene might be used to assess the risk of sepsis and multiple organ dysfunction syndrome (MODS) in trauma patients.
|
27023591 |
2016 |
|
Associated Pulmonary Arterial Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10865710 C allele was also associated with pulmonary arterial hypertension in the French SSc cohort (p=0.002; odds ratio=2.33 per C allele, 95% confidence interval 1.34-4.03).
|
25986483 |
2015 |
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the discovery cohort, a single PPARG intronic SNP (rs10865710) was associated with SSc (p=0.010; odds ratio=1.52 per C allele, 95% confidence interval 1.10-2.08).
|
25986483 |
2015 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped three potentially functional single nucleotide polymorphisms (SNPs) using Taqman - rs3734254 of the gene PPARD and rs10865710 and rs1801282 of the gene PPARG - and investigated their associations with lung and UADT cancer survival using Cox regression.
|
25043640 |
2014 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped three potentially functional single nucleotide polymorphisms (SNPs) using Taqman - rs3734254 of the gene PPARD and rs10865710 and rs1801282 of the gene PPARG - and investigated their associations with lung and UADT cancer survival using Cox regression.
|
25043640 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele frequency of rs10865710 in NAFLD group (41.1%) was significantly higher than that (34.8%) in controls (p = 0.03).
|
22820754 |
2012 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a stepwise forward selection procedure revealed that the T --> C (Val591Ala) polymorphism of APOB (rs679899), the -681C --> G polymorphism of PPARG (rs10865710), the T --> C (Cys1367Arg) polymorphism of WRN (rs1346044), the -850C --> T polymorphism of TNF (rs1799724), the -219G --> T polymorphism of APOE (rs405509), the C --> T polymorphism of PTGS1 (rs883484) and the 41A --> G (Glu14Gly) polymorphism of ACAT2 (rs9658625) were significantly (P<0.05) associated with the prevalence of CKD.
|
19282863 |
2009 |