|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
A subgroup analysis showed that the genetic models of rs10889677 polymorphism were associated with CD risk in Caucasians (p < 0.05), but not in Asians (p > 0.05).
|
31728561 |
2020 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Rs1884444 was found to confer risk for UC and psoriasis, rs10889677 for CD and psoriasis, while rs2201841 and rs7517847 had effect only in CD.
|
23093364 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis.
|
23054009 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed independent CD association for carriers of ATG16L1 (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.09-3.24), IBD5-IGR2230 (OR = 2.16, 95% CI 1.30-3.59), and IL23R-rs10889677 (OR = 2.13, 95% CI 1.39-3.28) while retaining association for NOD2 mutation carriers (OR = 4.45, 95% CI 2.68-7.38), IBD family history (OR = 2.75, 95% CI 1.42-5.31), tobacco (OR = 2.06, 95% CI 1.35-3.14), and Jewish ethnicity (OR = 20.1, 95% CI 2.16-186.8).
|
18521914 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%, p<0.05; and 13.2%, 13.1% vs 5.91%, p<0.05), but not in the SSc patients.
|
17606463 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
In addition, the allelic (CD: p < 0.00001, OR = 1.34; UC: p < 0.00001, OR = 1.22) and dominant models (CD: p = 0.002, OR = 1.39; UC: p = 0.01, OR = 1.29), but not the recessive model of rs10889677 polymorphism significantly increase the risk of CD and UC (p > 0.05).
|
31728561 |
2020 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups.
|
27902482 |
2017 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASDB |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Lack of association between rheumatoid arthritis and genetic variants rs10889677, rs11209026 and rs2201841 of IL-23R gene.
|
29370888 |
2018 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), -197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population.
|
28547498 |
2017 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data emphasise that the AA genotype of rs11209026 (Arg381Gln) was significantly associated with RA patients compared to the controls (P value=0.001).We did not find any significant association between either rs2201841 or rs10889677 and the development of rheumatoid arthritis (P value=1.000 & 0.562 respectively).
|
25858864 |
2015 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis.
|
23054009 |
2013 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed that bearing these alleles represent risk for the development of rheumatoid arthritis (chi(2) = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and chi(2) = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841).
|
17606463 |
2008 |
|
Malignant neoplasm of stomach
|
|
0.030 |
GeneticVariation
|
BEFREE |
The <i>let-7</i>-related polymorphism rs3811463 in <i>LIN28A</i> is associated with the susceptibility to gastric cancer and the <i>let-7</i>-related polymorphism rs10889677 in <i>IL23R</i> is associated with the prognosis of gastric cancer.
|
30833806 |
2019 |
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The <i>let-7</i>-related polymorphism rs3811463 in <i>LIN28A</i> is associated with the susceptibility to gastric cancer and the <i>let-7</i>-related polymorphism rs10889677 in <i>IL23R</i> is associated with the prognosis of gastric cancer.
|
30833806 |
2019 |
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that IL23R gene rs10889677 A allele confers increased risk of AS in Europeans, but its role in Asian populations needs further exploration.
|
29198991 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that CT (OR<sub>adj</sub> = 0.59; 95% CI: 0.44-0.79), CT + TT (OR<sub>adj</sub> = 0.58; 95% CI: 0.43-0.77) genotypes, and T allele (OR<sub>adj</sub> = 0.77; 95% CI: 0.47-0.80) of rs3748067 reduced GC risk; the rs10889677 CC genotype (OR<sub>adj</sub> = 2.22; 95% CI: 1.27-3.87) and C allele (OR<sub>adj</sub> = 1.24; 95% CI: 1.02-1.52) increased GC risk.
|
29118466 |
2017 |
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that CT (OR<sub>adj</sub> = 0.59; 95% CI: 0.44-0.79), CT + TT (OR<sub>adj</sub> = 0.58; 95% CI: 0.43-0.77) genotypes, and T allele (OR<sub>adj</sub> = 0.77; 95% CI: 0.47-0.80) of rs3748067 reduced GC risk; the rs10889677 CC genotype (OR<sub>adj</sub> = 2.22; 95% CI: 1.27-3.87) and C allele (OR<sub>adj</sub> = 1.24; 95% CI: 1.02-1.52) increased GC risk.
|
29118466 |
2017 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, rs10889677 may be associated with BC susceptibility and rs1884444 had association with HCC risk.
|
26717375 |
2015 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no evidence of a relationship between IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) and cancer risk was found in the overall population.Our meta-analysis provides no evidence supporting a global association of IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) with the risk of cancer.
|
26717375 |
2015 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, rs10889677 may be associated with BC susceptibility and rs1884444 had association with HCC risk.
|
26717375 |
2015 |