|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our findings are consistent with a true association between rs</span>10911021 and CHD in T2D.
|
27549350 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.730 |
GeneticVariation
|
BEFREE |
These results extend the association of GLUL rs10911021 to incident CVD morbidity and mortality in the setting of T2D.
|
26395743 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.730 |
GeneticVariation
|
BEFREE |
These findings point to SNP rs10911021 as an independent modulator of mortality in patients with type 2 diabetes and, together with the previous observation, suggest that this results from an effect of this variant on cardiovascular risk.
|
25677913 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.730 |
GeneticVariation
|
GWASCAT |
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.
|
23982368 |
2013 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
Over a median of 9.6 years of follow-up, the risk (C) allele for GLUL r</span>s10911021 was significantly associated with the primary composite end point of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina among individuals with no history of cardiovascular disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01-1.36]; P = 0.032).
|
26395743 |
2016 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.
|
23982368 |
2013 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The SNP rs10911021 was associated with CHD only in patients having diabetes, but the SNP was associated with total oxidative stress biomarkers MDA and GSH and GSSG levels.
|
29304826 |
2018 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings are consistent with a true association between rs</span>10911021</span> and CHD in T2D.
|
27549350 |
2016 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes.
|
25677913 |
2015 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (rs10911021) was identified that was significantly associated with CHD among persons with diabetes but not in those without diabetes and was functionally related to glutamic acid metabolism, suggesting a mechanistic link.
|
23982368 |
2013 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.
|
29304826 |
2018 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs10911021 was associated with CHD only in patients having diabetes, but the SNP was associated with total oxidative stress biomarkers MDA and GSH and GSSG levels.
|
29304826 |
2018 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs10911021 was associated with CHD only in patients having diabetes, but the SNP was associated with total oxidative stress biomarkers MDA and GSH and GSSG levels.
|
29304826 |
2018 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.
|
29304826 |
2018 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes.
|
25677913 |
2015 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes.
|
25677913 |
2015 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (rs10911021) was identified that was significantly associated with CHD among persons with diabetes but not in those without diabetes and was functionally related to glutamic acid metabolism, suggesting a mechanistic link.
|
23982368 |
2013 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (rs10911021) was identified that was significantly associated with CHD among persons with diabetes but not in those without diabetes and was functionally related to glutamic acid metabolism, suggesting a mechanistic link.
|
23982368 |
2013 |
|
Heart Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
As the SNP rs10911021 showed significant association with oxidative stress parameters and these parameters should an increased oxidative stress in the CHD subjects, it can be concluded that the SNP may have contributed to increase the risk of heart diseases in the diabetic subjects by increasing the oxidative stress.
|
29304826 |
2018 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association.
|
26395743 |
2016 |
|
Angina Pectoris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Over a median of 9.6 years of follow-up, the risk (C) allele for GLUL rs10911021 was significantly associated with the primary composite end point of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina among individuals with no history of cardiovascular disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01-1.36]; P = 0.032).
|
26395743 |
2016 |
|
Cardiovascular morbidity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study.
|
26395743 |
2016 |